X-Phos

Base Information Edit

Chemical Name:X-Phos
CAS No.:564483-18-7
Molecular Formula:C33H49P
Molecular Weight:476.726
Hs Code.:29319090
European Community (EC) Number:611-387-6
UNII:R271FU23T8
DSSTox Substance ID:DTXSID50457126
Nikkaji Number:J1.911.682D,J3.650.095F
Wikipedia:XPhos
Wikidata:Q8042433
Mol file:564483-18-7.mol

Synonyms:564483-18-7;X-Phos;XPhos;2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl;2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl;2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl;dicyclohexyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine;MFCD04117682;Xphos phosphine ligand [MI];2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl;UNII-R271FU23T8;dicyclohexyl[2-(2,4,6-triisopropylphenyl)phenyl]phosphane;2-dicyclohexylphosphino-2',4',6'-tri-isopropyl-1,1'-biphenyl;(2',4',6'-triisopropyl-1,1'-biphenyl-2-yl)dicyclohexylphosphine;R271FU23T8;Buchwald phosphine ligands, xphos phosphine ligand-;dicyclohexyl-[2-(2,4,6-triisopropylphenyl)phenyl]phosphane;2-(DICYCLOHEXYLPHOSPHINO)-2',4',6'-TRI(ISOPROPYL)BIPHENYL;2-(Dicyclohexylphosphino)-2',4',6'-triisopropyl-1,1'-biphenyl;dicyclohexyl-[2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane;dicyclohexyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphane;Phosphine, dicyclohexyl(2',4',6'-tris(1-methylethyl)(1,1'-biphenyl)-2-yl)-;PHOSPHINE, DICYCLOHEXYL[2',4',6'-TRIS(1-METHYLETHYL)[1,1'-BIPHENYL]-2-YL]-;dicyclohexyl[2',4',6'-tri(propan-2-yl)biphenyl-2-yl]phosphane;DICYCLOHEXYL(2',4',6'-TRIISOPROPYLBIPHENYL-2-YL)PHOSPHINE;dicyclohexyl[2',4',6'-tris(propan-2-yl)-[1,1'-biphenyl]-2-yl]phosphane;C33H49P;2-(Dicyclohexylphosphino)-2,4,6-Triisopropylbiphenyl;XPhos, 97%;SCHEMBL9618;DTXSID50457126;UGOMMVLRQDMAQQ-UHFFFAOYSA-N;2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl;BCP02360;CS-D1112;2-DICYCLOHEXYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL;BBL103618;STL557428;AKOS015840823;AC-1757;AM87070;GC10132;GS-4462;MB03341;2-Dicyclohexylphosphino-2 inverted exclamation mark ,4 inverted exclamation mark ,6 inverted exclamation mark -triisopropylbiphenyl;BP-21273;PD118787;SY008257;D5038;FT-0647539;EN300-66857;J3.650.095F;A15653;J-506349;Q8042433;Y-200001;2,4,6-triisopropyl-2'-(dicyclohexylphosphino)biphenyl;2,4,6-triisopropyl-2'-biscyclohexylphosphinobiphenyl;2-dicyclohexylphophino-2',4',6'-triisopropylbiphenyl;2-dicyclohexylphosphino 2',4'6'-triisopropylbiphenyl;2-dicyclohexylphosphino2',4',6'-triisopropylbiphenyl;2-dicylohexylphosphino-2',4',6'-triisopropylbiphenyl;2,4,6-triisopropyl-2'-(dicyclohexylphosphino) biphenyl;2-(dicyclohexylphosphino)2',4',6'-triisopropylbiphenyl;2-(dicyclohexylphospino)-2',4',6'-triisopropylbiphenyl;2-di-cyclohexylphosphino-2',4',6'-triisopropylbiphenyl;2-dicyclohexylphosphino-2', 4', 6'-triisopropylbiphenyl;2-dicyclohexylphosphino-2',4',6',-triisopropylbiphenyl;2-dicyclohexylphosphino-2',4',6'-triisopropyl biphenyl;2-dicyclohexylphosphino-2',4',6'-triisopropyl-biphenyl;F0001-1480;[2-(2,4,6-triisopropylphenyl)phenyl]dicyclohexylphosphine;2-(dicyclo-hexylphosphino)-2',4',6'-triisopropyl-biphenyl;2-(dicyclohexyl-phosphino)-2',4',6'-triisopropylbiphenyl;2-(dicyclohexylphosphino)-2', 4', 6'-triisopropylbiphenyl;2-(dicyclohexylphosphino)-2',4',6',-triisopropyl-biphenyl;2-(dicyclohexylphosphino)-2',4',6',-triisopropylbiphenyl;2-(dicyclohexylphosphino)-2',4',6'-tri-iso-propylbiphenyl;2-(dicyclohexylphosphino)-2',4',6'-triisopropyl-biphenyl;2-di-cyclohexylphosphino-2', 4', 6'-triisopropylbiphenyl;2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-biphenyl;2-dicylohexylphosphino-2',4',6'-triisopropyl-1,1-biphenyl;dicyclo-hexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine;dicyclohexyl (2',4',6'-triisopropylbiphenyl-2-yl)phosphine;Dicyclohexyl(2',4', 6'-triisopropylbiphenyl-2-yl)phosphine;dicyclohexyl(2',4',6'-triisopropyl-biphenyl-2-yl)phosphane;dicyclohexyl(2',4',6'-triisopropyl-biphenyl-2-yl)phosphine;dicyclohexyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphane;dicyclohexyl(2',4',6'-triisopropylbipheriyl-2-yl)phosphine;dicyclohexyl-(2',4',6'-triisopropylbiphenyl-2-yl)phosphine;dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl;X-Phos, ChemDose(TM) tablets, Loading: 2mumol per tablet;(aR)-2,4,6-Triisopropyl-2'-(dicyclohexylphosphino)biphenyl;2-(dicyclohexyl-phosphino)-2',4',6',-triisopropyl-biphenyl;2-(dicyclohexylphosphino)-2',4',6',-triisopropyl-bi-phenyl;2-(dicyclohexylphosphino)-2',4',6'-tris(isopropyl)-biphenyl;2-(dicyclohexylphosphino)-2'-,4'-,-6'-triisopropyl-biphenyl;2-(dicyclohexylphosphino)-2'-,4'-,6'-triisopropyl-biphenyl;2-dicyclohexylphosphino-2',4',6'-triiso-propyl-1,1'-biphenyl;2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1' biphenyl;2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1'biphenyl;2-dicyclohexylphosphino-2',4',6'-triisopropyl-1,1-biphenyl;2-dicyclohexylphosphino-2'4'6'-tri-iso-propyl-1,1' biphenyl;2-dicyclohexylphosphino-2'4'6'-tri-iso-propyl-1,1'biphenyl;2-dicylcohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl;dicyclohexyl (2',4',6'-triisopropylbiphenyl-2-yl) phosphine;Dicyclohexyl-(2',4',6'-triisopropyl-biphenyl-2-yl)-phosphane;dicyclohexyl-(2',4',6'-triisopropylbiphenyl-2-yl)-phosphine;dicyclohexyl-[2-(2,4,6-triisopropylphenyl)-phenyl]phosphane;2-(dicyclohexylphosphino)-2',4',6',-tri-i-propyl-1,1'-biphenyl;2-(dicyclohexylphosphino)-2',4',6',-tri-isopropyl-1,1'-biphenyl;2-(Dicyclohexylphosphino)-2',4',6'-tri-i -propyl-1,1'-biphenyl;2-(dicyclohexylphosphino)-2',4',6'-tri-iso-propyl-1,1'-biphenyl;2-(dicyclohexylphosphino)-2',4',6'-tri-isopropyl-1,1'-biphenyl;2-dicyclohexylphosphino-2',4',6',-tri-i-propyl-1,1'-biphenyl;2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl;dicyclohexyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2yl)phosphine;dicyclohexyl(2',4',6'-tris(1-methylethyl)-2-biphenylyl)phosphane;dicyclohexyl[2',4',6'-tris(1-methylethyl)biphenyl-2-yl]phosphane;dicyclohexyl[2',4',6'-tris(1-methylethyl)biphenyl-2-yl]phosphine;dicyclohexyl (2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine;dicyclohexyl[2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]-phosphine

Suppliers and Price of X-Phos

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
XPHOS
500mg
$ 45.00

TCI Chemical
2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl >98.0%(GC)
5g
$ 318.00

TCI Chemical
2-Dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl >98.0%(GC)
1g
$ 108.00

SynQuest Laboratories
X-phos 98%
25 g
$ 154.00

SynQuest Laboratories
X-phos 98%
1 g
$ 16.00

SynQuest Laboratories
X-phos 98%
5 g
$ 48.00

Strem Chemicals
2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl, min. 98% XPhos
100g
$ 2103.00

Strem Chemicals
2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl, min. 98% XPhos
500g
$ 3882.00

Strem Chemicals
2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl, min. 98% XPhos
500mg
$ 33.00

Strem Chemicals
2-(Dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1'-biphenyl, min. 98% XPhos
2g
$ 52.00

Total 196 raw suppliers

Chemical Property of X-Phos Edit

Chemical Property:

Appearance/Colour:White crystalline powder
Melting Point:187-190 °C(lit.)
Boiling Point:569.762 °C at 760 mmHg
Flash Point:317.745 °C
PSA：13.59000
LogP:10.49640
Storage Temp.:Inert atmosphere,Room Temperature
Sensitive.:Air Sensitive
Solubility.:Benzene (Slightly)
XLogP3:10.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:0
Rotatable Bond Count:7
Exact Mass:476.35718856
Heavy Atom Count:34
Complexity:545

Purity/Quality:

99%+ ^*data from raw suppliers

XPHOS ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 36/37/38-22-40
Safety Statements: 37/39-26-36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1=CC(=C(C(=C1)C(C)C)C2=CC=CC=C2P(C3CCCCC3)C4CCCCC4)C(C)C
Uses suzuki reaction Exceptional ligands for Pd-catalyzed amination and amidation of aryl sulfonates. XPHOS is used as a regent in the synthesis of novel [1,2,4]triazolo[4,3-a]pyrazine derivatives as potential selective c-met inhibitors with improved pharmacokinetic properties. XPHOS is used as a regent in the synthesis of novel [1,2,4]triazolo[4,3-a]pyrazine derivatives as potential selective c-met inhibitors with improved pharmacokinetic properties.

Technology Process of X-Phos

There total 6 articles about X-Phos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 462-06-6
fluorobenzene

: 717-74-8
1,3,5-triisopropyl benzene

: 16523-54-9
chlorodicyclohexylphosphane

: 564483-18-7
XPhos

Guidance literature:: fluorobenzene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

chlorodicyclohexylphosphane; In tetrahydrofuran; at 15 ℃; for 10h;

1,3,5-triisopropyl benzene; With n-butyllithium; potassium tert-butylate; In hexane; at 30 - 60 ℃; for 16h; Reagent/catalyst; Temperature;

Reference yield: 90.0%

: 2'-chloro-2,4,6-triisopropylbiphenyl

: 16523-54-9
chlorodicyclohexylphosphane

: 564483-18-7
XPhos

Guidance literature:: 2'-chloro-2,4,6-triisopropylbiphenyl; With n-butyllithium; at 0 ℃; for 1h;

chlorodicyclohexylphosphane; at 20 ℃; for 2h; Temperature; Reagent/catalyst;

Reference yield: 89.0%

: 21524-34-5
2,4,6-triisopropyl-1-bromobenzene

: 16523-54-9
chlorodicyclohexylphosphane

: 583-53-9
2,3-dibromobenzene

: 564483-18-7
XPhos

Guidance literature:: 2,4,6-triisopropyl-1-bromobenzene; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

2,3-dibromobenzene; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

chlorodicyclohexylphosphane; Further stages;