462-06-6 Usage
Chemical Description
Different sources of media describe the Chemical Description of 462-06-6 differently. You can refer to the following data:
1. Fluorobenzene is an organic compound with a fluorine atom attached to a benzene ring.
2. Fluorobenzene and azodicarboxylate are reactants used in the control experiments to gain insight into the mechanism.
Description
Fluorobenzene is a colourless, highly flammable liquid, stable and incompatible with oxidising
agents. It is not compatible with oxidising agents such as perchlorates, peroxides,
permanganates, chlorates, nitrates, chlorine, bromine and fluorine, ammonium nitrate,
chromic acid, halogens, and nitric acid. It is used as an insecticide and as a reagent for
plastic and resin polymers.
Chemical Properties
Different sources of media describe the Chemical Properties of 462-06-6 differently. You can refer to the following data:
1. colourless liquid
2. Fluorobenzene is a colorless liquid.
Uses
Different sources of media describe the Uses of 462-06-6 differently. You can refer to the following data:
1. Fluorobenzene is used as a reagent for plastic or resin polymers. It acts as a solvent for highly reactive species. On fluorination of fluorobenzene it gives 1,2-difluorobenzene. It is also used as a material in making medicine.
2. Insecticide and larvicide intermediate, identification reagent for plastic or resin polymers.
Definition
ChEBI: The simplest member of the class of monofluorobenzenes that is benzene carrying a single fluoro substituent.
Synthesis Reference(s)
Journal of the American Chemical Society, 106, p. 452, 1984 DOI: 10.1021/ja00314a050The Journal of Organic Chemistry, 30, p. 3170, 1965 DOI: 10.1021/jo01020a073
General Description
A clear, colorless liquid with a characteristic aromatic odor. About the same density as water. Flash point 5°F. Vapors heavier than air. May irritate the skin, eyes, and mucous membranes. Used as an insecticide, larvacide and as a reagent for plastic or resin polymers.
Air & Water Reactions
Highly flammable. Slightly soluble in water.
Reactivity Profile
Incompatible with strong oxidizing agents.
Health Hazard
Irritating to skin, eyes and mucous membranes. Repeated exposure of skin may cause dermatitis due to defatting action. Chronic inhalation of vapors or mist may result to damage to lungs, liver and kidneys. Acute vapor exposures can cause symptoms ranging from coughing to transient anesthesia and central nervous system depression.
Flammability and Explosibility
Highlyflammable
Safety Profile
: Mddly toxic by
ingestion and inhalation. A very dangerous
fire hazard when exposed to heat, flame, or
oxidizers. To fight fire, use water spray,
mist, foam, dry chemical, CO2. When heated
to decomposition it emits toxic fumes of F-
Potential Exposure
Fluorobenzene is used as an insecti cide and as a reagent for plastic or resin polymers.
Shipping
UN2387 Fluorobenzene, Hazard Class: 3;
Labels: 3-Flammable liquid.
Purification Methods
Dry fluorobenzene for several days with P2O5, then fractionally distil it. [Beilstein 5 H 198, 5 IV 632.]
Incompatibilities
Vapor may form explosive mixture with
air. Incompatible with oxidizers (chlorates, nitrates, perox ides, permanganates, perchlorates, chlorine, bromine, fluo rine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides.
Check Digit Verification of cas no
The CAS Registry Mumber 462-06-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 2 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 462-06:
(5*4)+(4*6)+(3*2)+(2*0)+(1*6)=56
56 % 10 = 6
So 462-06-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H5F/c7-6-4-2-1-3-5-6/h1-5H
462-06-6Relevant articles and documents
Fluoroaromatics from arylamines, a convenient one-pot conversion using nitrosonium tetrafluoroborate
Milner
, p. 73 - 82 (1992)
A simple, novel and extremely versatile procedure has been identified for the conversion of arylamines into the corresponding arylfluorides. The amine is treated with nitrosonium tetrafluoroborate in dichloromethane and the resulting diazonium tetrafluoroborate is heated, without isolation or drying, to give the fluoroaromatic, generally in good yield. The method is applicable even to arylamines bearing carboxyl and hydroxyl substituents which give poor yields of arylfluorides under Balz-Schiemann conditions.
Cleavage of Aryl-Tin Bonds with Elemental Fluorine: Rapid Synthesis of Fluorobenzene
Adam, Michael J.,Pate, Brian D.,Ruth, Thomas J.,Berry, Joffre M.,Hall, Laurance D.
, p. 733 (1981)
Fluorobenzene has been synthesized rapidly by treatment of aryltin derivatives with F2 in CFCl3 or CCl4 at -78 to 0 deg C.
DIRECT LIQUID-PHASE FLUORINATION OF AROMATIC COMPOUNDS. NEW ADVANCES IN ELECTROPHILIC FLUORINATION
Gambaretto, G. P.,Conte, L.,Fraccaro, C.,Napoli, M.
, p. 241 (1991)
-
Preparation of Fluoroarenes in One-Pot Diazotization and Fluoro-Dediazoniation of Aminoarenes Using HF or HF-Base. The Functions of Bases in the HF Solution
Fukuhara, Tsuyoshi,Sasaki, Satoshi,Yoneda, Norihiko,Suzuki, Akira
, p. 2058 - 2062 (1990)
In a one-pot diazotization of anilines followed by fluoro-dediazoniation in situ using HF or HF with bases (HF-Base) as a solvent, the diazotization stage has been found to play the most important part to yield fluoroarenes effectively.Diazotization of anilines was greatly influenced by the composition of the HF solution, and greatly enhanced by employing appropriate amounts of bases, such as pyridine.On the other hand, fluoro-dediazoniation of diazonium salts, once formed, took place very readily in HF or HF-Base to produce fluoroarenes in high yield, although such bases served to slow down the rate of decomposition of diazonium salts to some extent.
-
Feng,Mamula
, p. 507 (1958)
-
Speranza et al.
, p. 5583,5588 (1977)
Photochemical Sandmeyer-type Halogenation of Arenediazonium Salts
Belitz, Florian,Goo?en, Lukas J.,Manu Martínez, ángel,Schmid, Rochus,Sivendran, Nardana,Sowa Prendes, Daniel
, (2022/01/19)
Trihalide salts were found to efficiently promote photochemical dediazotizing halogenations of diazonium salts. In contrast to classical Sandmeyer reactions, no metal catalysts are required to achieve high yields and outstanding selectivities for halogena
Mechanistic studies into visible light-driven carboxylation of aryl halides/triflates by the combined use of palladium and photoredox catalysts
Caner, Joaquim,Iwasawa, Nobuharu,Martin, Ruben,Murata, Kei,Shimomaki, Katsuya,Toriumi, Naoyuki
supporting information, p. 1846 - 1853 (2021/08/13)
The reaction mechanism of palladium-catalyzed visible light-driven carboxylation of aryl halides and triflates with a photoredox catalyst was examined in detail. Experimental and theoretical studies indicated that the active species for photoredox- catalyzed reduction was cationic ArPd(II)+ species to generate nucleophilic ArPd(I) or its further reduced ArPd(0)- species, which reacted with CO2 to give carboxylic acids. Hydrodehalogenated compounds, main byproducts in this carboxylation, were thought to be generated by protonation of these reduced species.
