Technology Process of Boronic acid, [6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]-
There total 4 articles about Boronic acid, [6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indol-3-yl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-tosyl-3,6-dibromoindole;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 0.666667h;
With
Trimethyl borate;
In
tetrahydrofuran; pentane;
at -78 ℃;
for 2h;
DOI:10.3987/COM-00-8890
- Guidance literature:
-
6-bromo-1-(4-methylphenylsulfonyl)-1H-indole;
With
mercury(II) diacetate;
In
acetic acid;
at 20 ℃;
With
dimethylsulfide; borane;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
With
water;
DOI:10.1016/S0968-0896(01)00070-0
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 4 h
2.1: perchloric acid; mercury(II) diacetate; acetic acid / 24 h
2.2: BH3*THF / 1 h / 23 °C
2.3: water
With
potassium hydroxide; perchloric acid; mercury(II) diacetate; tetra(n-butyl)ammonium hydrogensulfate; acetic acid;
In
toluene;
DOI:10.1021/ja027822b
