2-AMino-4-(3-indolyl)pyriMidine

Base Information

• Chemical Name: 2-AMino-4-(3-indolyl)pyriMidine
• CAS No.: 289628-76-8
• Molecular Formula: C12H10N4
• Molecular Weight: 210.238
• Hs Code.: 2933990090
• Mol file: 289628-76-8.mol

Synonyms:3-(2-aminopyrimidin-4-yl)-1H-indole;Meridianin G;4-(1H-indol-3-yl)-2-pyrimidinamine;2-AMINO-4-(3-INDOLYL)PYRIMIDINE;debromomeridianin D;6-debromomeridianin D;

Chemical Property of 2-AMino-4-(3-indolyl)pyriMidine

Chemical Property:

• PSA: 67.59000
• LogP: 2.78830

Purity/Quality:

98%min ^*data from raw suppliers

4-(1H-indol-3-yl)pyrimidin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMino-4-(3-indolyl)pyriMidine

There total 25 articles about 2-AMino-4-(3-indolyl)pyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tert-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate (942070-45-3) + 2-amino-4-chloropyrimidine (3993-78-0) → 4-(1H-indol-3-yl)pyrimidin-2-amine (289628-76-8)

Guidance literature:

With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); caesium carbonate; In water; isopropyl alcohol; at 80 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1021/om500420d

Reference yield: 87.0%

C13H10N4O2 (928203-39-8) → 4-(1H-indol-3-yl)pyrimidin-2-amine (289628-76-8)

Guidance literature:

With sulfuric acid; at 90 - 120 ℃; for 6h;

DOI:10.1016/j.bmc.2006.11.023

Reference yield: 83.0%

C26H36N4O6SSi (1538583-13-9) → 4-(1H-indol-3-yl)pyrimidin-2-amine (289628-76-8)

Guidance literature:

C₂₆H₃₆N₄O₆SSi; With hydrogenchloride; In methanol; water; Reflux;

With sodium hydroxide; In methanol; water; for 4.5h; pH=14; Reflux;

DOI:10.1021/ol403390m

upstream raw materials:

guanidine nitrate

C₁₃H₁₀N₄O₂

guanidine hydrochloride

3-Dimethylamino-1-(3-indolyl)-2-propen-1-one