(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

Base Information

Chemical Name:(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester
CAS No.:191786-76-2
Molecular Formula:C₄₀H₄₂F₆N₅O₁₀P
Molecular Weight:897.765
Hs Code.:

(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

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Chemical Property of (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

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Technology Process of (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

There total 1 articles about (R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 920-66-1
1,1,1,3',3',3'-hexafluoro-propanol

: C₄₃H₅₅N₆O₈P

: (S)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

: 191786-76-2
(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

Guidance literature:: With pyridine; 1H-tetrazole; iodine; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₃CN, room temperature, 3 min, 2.) THF, H₂O, room temperature, 20 min;
DOI:10.1080/07328319708001359

Reference yield:

: N-{9-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl]-9H-purin-6-yl}-benzamide

: 191786-76-2
(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

: C₅₅H₅₉N₁₀O₁₄P

: C₅₅H₅₉N₁₀O₁₄P

Guidance literature:: With 3-ethyl-3-pentanoxymagnesium chloride; tetrabutyl ammonium fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, 60-65 deg C, 2.) THF, room temperature, 2 h;
DOI:10.1080/07328319708001359

Reference yield:

: N-{1-[(2R,3R,4R,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-hydroxymethyl-3-methoxy-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-isobutyramide

: 191786-76-2
(R)-Methyl-phosphonic acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-4-methoxy-tetrahydro-furan-3-yl ester 2,2,2-trifluoro-1-trifluoromethyl-ethyl ester

: C₅₁H₆₁N₈O₁₅P

: C₅₁H₆₁N₈O₁₅P

Guidance literature:: With 3-ethyl-3-pentanoxymagnesium chloride; tetrabutyl ammonium fluoride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, 60-65 deg C, 2.) THF, room temperature, 2 h;
DOI:10.1080/07328319708001359