Technology Process of 9-Octadecen-12-ynoic acid, methyl ester, (9Z)-
There total 6 articles about 9-Octadecen-12-ynoic acid, methyl ester, (9Z)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3-nonyn-1-yl)triphenylphosphonium iodide;
With
potassium hexamethylsilazane;
In
tetrahydrofuran; toluene;
at -78 - 0 ℃;
for 0.25h;
Inert atmosphere;
methyl ester of azelaic acid aldehyde;
In
tetrahydrofuran; toluene;
at -78 - 20 ℃;
DOI:10.1021/acs.orglett.5b02814
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridinium chlorochromate / dichloromethane / 3 h / 20 °C / Inert atmosphere; Molecular sieve
2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -78 - 0 °C / Inert atmosphere
2.2: -78 - 20 °C
With
potassium hexamethylsilazane; pyridinium chlorochromate;
In
tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/acs.orglett.5b02814
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene / 20 h / 80 °C / Inert atmosphere
2.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.25 h / -78 - 0 °C / Inert atmosphere
2.2: -78 - 20 °C
With
potassium hexamethylsilazane;
In
tetrahydrofuran; toluene;
DOI:10.1021/acs.orglett.5b02814