Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl bis(1-methylethyl)phosphoramidite]

Base Information

• Chemical Name: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl bis(1-methylethyl)phosphoramidite]
• CAS No.: 291299-92-8
• Molecular Formula: C₅₆H₆₆N₅O₁₀P
• Molecular Weight: 1000.14
• Mol file: 291299-92-8.mol

Synonyms:

Chemical Property of Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl bis(1-methylethyl)phosphoramidite]

Chemical Property:

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Useful:

Technology Process of Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl bis(1-methylethyl)phosphoramidite]

There total 5 articles about Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-[(4-methoxybenzoyl)(1-methylethyl)amino]ethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) + N,N,N',N'-tetraisopropyl-O-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethyl] phosphordiamidite (327596-87-2) → N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethoxy]phosphinyl-2'-deoxycytidine (291299-92-8,291300-22-6,291300-23-7)

Guidance literature:

With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/ja0016396

Reference yield:

bis(diisopropylamino)chlorophosphine (56183-63-2) → N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethoxy]phosphinyl-2'-deoxycytidine (291299-92-8,291300-22-6,291300-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / iPr₂NEt / CH₂Cl₂

2: 1H-tetrazole / CH₂Cl₂

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1081/NCN-100002480

Reference yield:

N-(2-hydroxyethyl)-N-isopropyl-4-methoxybenzamide (291299-78-0) → N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(N,N-diisopropylamino)-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethoxy]phosphinyl-2'-deoxycytidine (291299-92-8,291300-22-6,291300-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / iPr₂NEt / CH₂Cl₂

2: 1H-tetrazole / CH₂Cl₂

With 1H-tetrazole; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1081/NCN-100002480

upstream raw materials:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

N,N,N',N'-tetraisopropyl-O-[2-[N-isopropyl-N-(4-methoxybenzoyl)amino]ethyl] phosphordiamidite

bis(diisopropylamino)chlorophosphine

N-(2-hydroxyethyl)-N-isopropyl-4-methoxybenzamide

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