327596-87-2Relevant academic research and scientific papers
Novel phosphate and thiophosphate protecting groups
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, (2008/06/13)
Novel P(III) bisamidite reagents as phosphorus protecting groups, nucleoside phosphoramidite intermediates, and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared through the protection of one or more int
Phosphate and thiophosphate protecting groups
-
, (2008/06/13)
Novel P(III) bisamidite reagents as phosphorus protecting groups, nucleoside phosphoramidite intermediates, and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared through the protection of one or more int
A novel protecting strategy for internucleosidic phosphate and phosphorothioate groups
Guzaev,Manoharan
, p. 1011 - 1014 (2007/10/03)
The utility of 2-(N-isopropyl-N-anisoylamino)ethyl group for protection of intemucleosidic phosphate linkages in oligonucleotide synthesis was studied. The group demonstrated high coupling yields, favorable deprotection kinetics and a high hydrolytic stability of phosphoramidite building blocks. The mechanism of deprotection was established using a model phosphate triester.
2-Benzamidoethyl group - A novel type of phosphate protecting group for oligonucleotide synthesis
Guzaev,Manoharan
, p. 783 - 791 (2007/10/03)
A number of 5′-O-(4,4′-dimethoxytrityl)thymidine N,N-diisopropylamino phosphoramidites protected at P(III) with derivatives of 2-benzamidoethanol were synthesized and incorporated into synthetic oligonucleotides. Depending on substitution patterns at the
