2-METHYL-N-P-TOLYL-ACRYLAMIDE

Base Information

• Chemical Name: 2-METHYL-N-P-TOLYL-ACRYLAMIDE
• CAS No.: 2918-73-2
• Molecular Formula: C11H13NO
• Molecular Weight: 175.23
• Mol file: 2918-73-2.mol

Synonyms:N-p-Tolyl-methacrylamid;Methacrylsaeure-p-toluidid;N-(4-methylphenyl)-2-methylprop-2-enamide;N-(p-tolyl)methacrylamide;methacrylic acid p-toluidide;N-(4-methylphenyl)methacrylamide;2-Methyl-N-p-tolyl-acrylamide;

Chemical Property of 2-METHYL-N-P-TOLYL-ACRYLAMIDE

Chemical Property:

• Melting Point: 82 - 83 °C
• PSA: 29.10000
• LogP: 2.58260

Purity/Quality:

99% ^*data from raw suppliers

2-METHYL-N-(4-METHYLPHENYL)ACRYLAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-METHYL-N-P-TOLYL-ACRYLAMIDE

There total 5 articles about 2-METHYL-N-P-TOLYL-ACRYLAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

p-toluidine (106-49-0,12221-03-3) + Methacryloyl chloride (920-46-7,26937-45-1) → 2-methyl-N-p-tolylacrylamide (2918-73-2)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1055/s-0037-1611560

Reference yield: 73.0%

1-methyl-4-nitrobenzene (99-99-0) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → 2-methyl-N-p-tolylacrylamide (2918-73-2)

Guidance literature:

1-methyl-4-nitrobenzene; With samarium diiodide; In tetrahydrofuran; at 20 ℃; for 0.166667h;

methacrylic acid methyl ester; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/jccs.200500133

Reference yield:

2-phenylacrylyl chloride (51491-68-0) + p-toluidine (106-49-0,12221-03-3) → 2-methyl-N-p-tolylacrylamide (2918-73-2)

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/acs.orglett.6b02706

upstream raw materials:

ethylmagnesium bromide

p-toluidine

methacrylic acid methyl ester

Methacryloyl chloride