2-phenylacrylyl chloride

Base Information

• Chemical Name: 2-phenylacrylyl chloride
• CAS No.: 51491-68-0
• Molecular Formula: C₉H₇ClO
• Molecular Weight: 166.607
• Mol file: 51491-68-0.mol

Synonyms:2-phenylacrylyl chloride

Chemical Property of 2-phenylacrylyl chloride

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenylacrylyl chloride

There total 13 articles about 2-phenylacrylyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tropoyl chloride (149423-39-2) → 2-phenylacrylic acid (492-38-6) + 2-phenylacrylyl chloride (51491-68-0)

Guidance literature:

bei der Destillation;

Reference yield:

2-phenylacrylic acid (492-38-6) → 2-phenylacrylyl chloride (51491-68-0)

Guidance literature:

With thionyl chloride;

Reference yield:

phenylacetic acid (103-82-2) → 2-phenylacrylyl chloride (51491-68-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / 2 h / Reflux

2: potassium carbonate; tetra-(n-butyl)ammonium iodide / toluene / 12 h / 50 °C

3: sodium hydroxide / 2 h / Reflux

4: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere

With oxalyl dichloride; sulfuric acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; toluene;

DOI:10.1002/anie.201700195

upstream raw materials:

2-phenylacrylic acid

tropoyl chloride

phenylacetic acid

Tropic acid

Downstream raw materials:

α-phenylacrylanilide

1-morpholino-2-phenylprop-2-en-1-one

2-Phenyl-acrylic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

2-Phenyl-acrylic acid (1S,3S,5R)-8-methyl-8-aza-bicyclo[3.2.1]oct-6-en-3-yl ester