3-[(4-NITROPHENYL)METHYLENE]-2,4-PENTANEDIONE

Base Information

• Chemical Name: 3-[(4-NITROPHENYL)METHYLENE]-2,4-PENTANEDIONE
• CAS No.: 29197-16-8
• Molecular Formula: C12H11NO4
• Molecular Weight: 233.224
• Mol file: 29197-16-8.mol

Synonyms:3-(4-Nitro-benzylidene)-pentane-2,4-dione;3-(4-Nitrobenzylidene)-pentane-2,4-dione;3-(4-nitrophenyl)methylene-2,4-pentanedione;

Chemical Property of 3-[(4-NITROPHENYL)METHYLENE]-2,4-PENTANEDIONE

Chemical Property:

• PSA: 79.96000
• LogP: 2.67940

Purity/Quality:

99% ^*data from raw suppliers

3-[(4-Nitrophenyl)methylene]-2,4-pentanedione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(4-NITROPHENYL)METHYLENE]-2,4-PENTANEDIONE

There total 10 articles about 3-[(4-NITROPHENYL)METHYLENE]-2,4-PENTANEDIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-nitrobenzaldehdye (555-16-8) + acetylacetone (123-54-6,81235-32-7) → 3-(4-nitrobenzylidene)pentane-2,4-dione (29197-16-8)

Guidance literature:

With papain; In water; dimethyl sulfoxide; at 60 ℃; for 120h; Enzymatic reaction;

DOI:10.1016/j.biochi.2011.09.018

Reference yield: 82.0%

4-acetoxy-3-penten-2-one (41002-50-0) + 4-nitrobenzaldehdye (555-16-8) → 3-(4-nitrobenzylidene)pentane-2,4-dione (29197-16-8)

Guidance literature:

With Porcine Pancreas Lipase; In water; tert-butyl alcohol; at 20 ℃; for 72h; Solvent; Temperature; Enzymatic reaction;

DOI:10.1002/chem.201901491

Reference yield: 51.0%

C8H12O3 + 4-nitrobenzaldehdye (555-16-8) → 3-(4-nitrobenzylidene)pentane-2,4-dione (29197-16-8)

Guidance literature:

With Porcine Pancreas Lipase; In water; tert-butyl alcohol; at 20 ℃; for 72h; Solvent; Temperature; Enzymatic reaction;

DOI:10.1002/chem.201901491

upstream raw materials:

sodium acetylacetonate

4-nitrobenzaldehdye

acetylacetone

piperidine

Downstream raw materials:

5-Acetyl-6-methyl-2-methylsulfanyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonitrile

6-Oxy-2-methylthio-6-methyl-4-(p-nitrophenyl)-5-acetyl-3-cyano-1,4,5,6-tetrahydropyridine

5-Acetyl-2-mercapto-6-methyl-4-(4-nitro-phenyl)-1,4-dihydro-pyridine-3-carbonitrile; compound with piperidine

3-(4-nitrobenzyl)pentane-2,4-dione