Thieno[2,3-b]pyridine-5-carboxamide, N-[(4-chlorophenyl)methyl]-4,7-dihydro-7-methyl-2-(4-morpholinylmethyl) -4-oxo-

Base Information

Chemical Name:Thieno[2,3-b]pyridine-5-carboxamide, N-[(4-chlorophenyl)methyl]-4,7-dihydro-7-methyl-2-(4-morpholinylmethyl) -4-oxo-
CAS No.:292144-10-6
Molecular Formula:C21H22ClN3O3S
Molecular Weight:431.943
Hs Code.:
Mol file:292144-10-6.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thieno[2,3-b]pyridine-5-carboxamide, N-[(4-chlorophenyl)methyl]-4,7-dihydro-7-methyl-2-(4-morpholinylmethyl) -4-oxo-

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Technology Process of Thieno[2,3-b]pyridine-5-carboxamide, N-[(4-chlorophenyl)methyl]-4,7-dihydro-7-methyl-2-(4-morpholinylmethyl) -4-oxo-

There total 11 articles about Thieno[2,3-b]pyridine-5-carboxamide, N-[(4-chlorophenyl)methyl]-4,7-dihydro-7-methyl-2-(4-morpholinylmethyl) -4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 292144-15-1,863102-07-2
N-(4-chlorobenzyl)-4-hydroxy-2-(4-morpholinylmethyl)thieno[2,3-b]pyridine-5-carboxamide

: 74-88-4
methyl iodide

: 292144-10-6
PNU-243672

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm050162b

Reference yield:

: 292144-09-3
N-(4-chlorobenzyl)-2-(hydroxymethyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide

: 110-91-8,99108-56-2
morpholine

: 292144-10-6
PNU-243672

Guidance literature:: With dmap; methanesulfonyl chloride; In N,N-dimethyl-formamide;

Reference yield:

: 292143-49-8
N-(4-chlorobenzyl)-4-hydroxythieno[2,3-b]pyridine-5-carboxamide

: 292144-10-6
PNU-243672

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / aq. acetic acid / ethanol / 42 h / Heating

2: 78 percent / K₂CO₃ / dimethylformamide / 18 h / 20 °C

With potassium carbonate; acetic acid; In ethanol; N,N-dimethyl-formamide; 1: Mannich reaction;
DOI:10.1021/jm050162b