Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:294653-58-0
Molecular Formula:C14H16N2O4
Molecular Weight:276.292
Hs Code.:
Mol file:294653-58-0.mol

Synonyms:4-(3-Hydroxy-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester;5-(ethoxycarbonyl)-4-(3-hydroxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one;oxo-monastrol;ethyl (+/-)-4-(3'-hydroxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate;ethyl-4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate;ethyl 4-(3-hydroxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate;5-ethoxycarbonyl-4-(3-hydroxyphenyl)-6-methyl-3,4-dihydro-pyrimidin-2(1H)-one;

Suppliers and Price of Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property:

Melting Point:187-188 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
Boiling Point:439.3±45.0 °C(Predicted)
PKA:9.74±0.10(Predicted)
PSA：87.66000
Density:1.250±0.06 g/cm3(Predicted)
LogP:2.24080

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 4 articles about Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 141-97-9
ethyl acetoacetate

: 100-83-4
meta-hydroxybenzaldehyde

: 57-13-6
urea

: 294653-58-0
ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With 2Fe⁽³⁺⁾*7Cl^(1-)*C₇H₁₃N₂O₃S⁽¹⁺⁾; at 90 ℃; for 4h; Ionic liquid; Schlenk technique;
DOI:10.1021/cs400291t

Reference yield: 79.0%

: 620-24-6
3-Hydroxybenzyl alcohol

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 294653-58-0
ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: 3-Hydroxybenzyl alcohol; With bismuth(III) nitrate; In acetonitrile; Heating;

ethyl acetoacetate; urea; In acetonitrile; Heating;
DOI:10.3987/COM-04-10257

Reference yield:

: 851778-73-9,851778-80-8
C₁₆H₁₈N₂O₅

: 294653-58-0
ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: C₁₆H₁₈N₂O₅; With water; potassium carbonate; In methanol; at 25 ℃; for 0.5h;

With hydrogenchloride; In methanol; water;