1-(3,4,5-Trimethoxyphenyl)Propan-1-Ol

Base Information

• Chemical Name: 1-(3,4,5-Trimethoxyphenyl)Propan-1-Ol
• CAS No.: 29652-81-1
• Molecular Formula: C12H18O4
• Molecular Weight: 226.273
• Mol file: 29652-81-1.mol

Synonyms:Aethyl-(3.4.5-trimethoxy-phenyl)-carbinol;ethyl-(3.4.5-trimethoxy-phenyl)-carbinol;11-Oxy-3.4.5-trimethoxy-1-propyl-benzol;1-(3,4,5-trimethoxyphenyl)propan-1-ol;

Chemical Property of 1-(3,4,5-Trimethoxyphenyl)Propan-1-Ol

Chemical Property:

• PSA: 47.92000
• LogP: 2.15580

Purity/Quality:

99% ^*data from raw suppliers

1-(3,4,5-Trimethoxyphenyl)propan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3,4,5-Trimethoxyphenyl)Propan-1-Ol

There total 4 articles about 1-(3,4,5-Trimethoxyphenyl)Propan-1-Ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethylmagnesium bromide (925-90-6) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → 1-(3,4,5-trimethoxyphenyl)-1-propanol (29652-81-1)

Guidance literature:

ethylmagnesium bromide; 3,4,5-trimethoxy-benzaldehyde; In tetrahydrofuran; at -5 ℃; Reflux;

With hydrogenchloride; water;

DOI:10.1016/j.bmc.2009.09.039

Reference yield: 79.0%

ethyl bromide (74-96-4) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → 1-(3,4,5-trimethoxyphenyl)-1-propanol (29652-81-1)

Guidance literature:

ethyl bromide; With magnesium; In diethyl ether; for 2h;

3,4,5-trimethoxy-benzaldehyde; In diethyl ether; toluene; at 20 ℃;

DOI:10.1246/bcsj.77.2231

Reference yield: 79.0%

ethyl bromide (74-96-4) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) → 1-(3,4,5-trimethoxyphenyl)-1-propanol (29652-81-1) + 3-(3,4,5-trimethoxyphenyl)-3-pentanol (267003-32-7)

Guidance literature:

ethyl bromide; With magnesium; In diethyl ether;

3,4,5-trimethoxy-benzaldehyde; In diethyl ether; toluene; at 20 ℃; for 14h;

DOI:10.1016/j.tet.2005.10.051

upstream raw materials:

ethylmagnesium bromide

3,4,5-trimethoxy-benzaldehyde

ethyl bromide

Downstream raw materials:

1-(3,4,5-trimethoxyphenyl)propan-1-one

Refernces

• 1、 Yan, Jun,Chen, Jie,Zhang, Shun,Hu, Jinhui,Huang, Ling,Li, Xingshu. "Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo". . p. 5264 - 5283. Retrieved 2016/07/06.
• 2、 Tanpure, Rajendra P.,Harkrider, Amanda R.,Strecker, Tracy E.,Hamel, Ernest,Trawick, Mary Lynn,Pinney, Kevin G.. "Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents". supporting information; experimental part. p. 6993 - 7001. Retrieved 2009/12/24.