N-Acetyl-L-tyrosylglycinamide

Base Information

• Chemical Name: N-Acetyl-L-tyrosylglycinamide
• CAS No.: 29701-41-5
• Molecular Formula: C13H17N3O4
• Molecular Weight: 279.296
• DSSTox Substance ID: DTXSID90559572
• Wikidata: Q82442326
• Mol file: 29701-41-5.mol

Synonyms:N-Acetyl-L-tyrosylglycinamide;29701-41-5;DTXSID90559572

Chemical Property of N-Acetyl-L-tyrosylglycinamide

Chemical Property:

• PSA: 129.49000
• LogP: 1.87120
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 279.12190603
• Heavy Atom Count: 20
• Complexity: 365

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NCC(=O)N
• Isomeric SMILES: CC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)NCC(=O)N

Technology Process of N-Acetyl-L-tyrosylglycinamide

There total 7 articles about N-Acetyl-L-tyrosylglycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-acetyl-L-tyrosine ethyl ester (840-97-1) + glycine amide hydrobromide (55264-42-1) → Ac-Tyr-Gly-NH2 (29701-41-5)

Guidance literature:

With α-chymotrypsin; In water; triethylamine; isopropyl alcohol; at 30 ℃; for 4h;

Reference yield:

N-acetyl-L-tyrosine ethyl ester (840-97-1) + glycine amide hydrobromide (55264-42-1) → N-acetyl-L-tyrosine (537-55-3) + Ac-Tyr-Gly-NH2 (29701-41-5) + N-acetyltyrosine isopropyl ester (124731-84-6)

Guidance literature:

With α-chymotryosin; triethylamine; In water; isopropyl alcohol; at 30 ℃; for 2h; Product distribution; pH 9.5; various content of water; other solvents, other aliphatic alcohols;

Reference yield:

N-(N-acetyl-L-tyrosyl)-glycine ethyl ester → Ac-Tyr-Gly-NH2 (29701-41-5)

Guidance literature:

With methanol; ammonia;

upstream raw materials:

N-acetyl-L-tyrosine ethyl ester

glycine amide hydrobromide

H-Gly-NH₂

N-acetyltyrosine hydrazide