537-55-3

Basic information

• Product Name: N-Acetyl-L-tyrosine
• Synonyms: L-TYROSINE, N-ACETYL-;ACETYLTYROSINE;ACETYL-L-TYROSINE;AC-TYR-OH;AC-TYROSINE;N-AC-L-TYR;N-ACETYL-L-TYROSINE;N-ACEYL-L-TYROSINE
• CAS NO: 537-55-3
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.23
• EINECS: 208-671-3
• Product Categories: Amino Acid;amino;Amino Acid Derivatives;Amino Acids;Tyrosine [Tyr, Y];Ac-Amino Acids;Amino Acids (N-Protected);Biochemistry;Nutritional Supplements;Pharmaceutical Intermediates;N-Acetyl-Amino acid series;Amino acids;Biochemicals Found in Plants;Nutrition Research;Pharmacopoeial Amino AcidsPeptide Synthesis;Amino Acid Derivatives;Amino acidsPharmacopoeia (USP);Pharmacopoeia A-ZPharmacopoeia (USP);Tyrosine
• Mol File: 537-55-3.mol
• Article Data: 54

Chemical Properties

• Melting Point: 149-152 °C(lit.)
• Boiling Point: 364.51°C (rough estimate)
• Flash Point: 275.1 °C
• Appearance: /Crystalline
• Density: 1.2446 (rough estimate)
• Vapor Pressure: 4.07E-12mmHg at 25°C
• Refractive Index: 1.4960 (estimate)
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble25mg/mL
• PKA: 3.15±0.10(Predicted)
• Water Solubility: Soluble in water (25 mg/ml), and ethanol.
• Stability: Stable. Incompatible with strong oxidizing agents.
• BRN: 2697172
• CAS DataBase Reference: N-Acetyl-L-tyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl-L-tyrosine(537-55-3)
• EPA Substance Registry System: N-Acetyl-L-tyrosine(537-55-3)

Safety Data

• Hazard Codes: Xi
• Statements: 41-36/37/38
• Safety Statements: 26-39-36
• WGK Germany: 3
• F: 10
• TSCA: Yes
• Hazardous Substances Data: 537-55-3(Hazardous Substances Data)

Usage

Chemical Properties

N-Acetyl-L-Tyrosine is a white crystalline powder that is an acetyl derivative of the amino acid, L-tyrosine. It is freely soluble in water compared to L-tyrosine and is commonly used as a parenteral nutrition supplement. N-Acetyl-L-tyrosine , a stable and more soluble form of tyrosine , has been incorporated in some currently available commercial parenteral amino acid formulations such as TrophAmine and Aminosyn-II.

Uses

N-Acetyl-L-tyrosine is involved in catecholamine production. It can be used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Definition

ChEBI: N-acetyl-L-tyrosine is an N-acetyltyrosine in which the chiral centre has L configuration. It has a role as an EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitor, a biomarker and a human urinary metabolite. It is a N-acyl-L-tyrosine and a N-acetyltyrosine. It is a conjugate acid of a N-acetyl-L-tyrosinate.

Application

N-Acetyl-L-tyrosine is a tyrosine derivative with a chemical structure similar to that of an amino acid. It is used as a model system in biochemistry and molecular biology to study the transfer reactions of tyrosine, which are important for energy metabolism, protein synthesis, and metal chelation. N-acetyl-L-tyrosine may be used as an indicator to distinguish neurosyphilis patients from syphilis/non-neurosyphilis patients. N-acetyl-L-tyrosine is a precursor of the essential neurotransmitter dopamine.

benefits

N-Acetyl-L-Tyrosine (NALT) plays a necessary part in the synthesis of dopamine and other hormones in your body. It can boost levels of the neurotransmitters dopamine, norepinephrine and epinephrine. It helps to support higher levels of focus and cognitive function. It can increase working memory and feelings of well-being.

Side effects

L-tyrosine gets the generally regarded as safe (GRAS) stamp of approval from the FDA. Some side effects of N-Acetyl-L-tyrosine (NALT) include nausea, headache, fatigue, and heartburn. It can be safely taken for extended periods of time.

InChI:InChI=1/C11H13NO4/c1-7(13)12-10(11(15)16)6-8-2-4-9(14)5-3-8/h2-5,10,14H,6H2,1H3,(H,12,13)(H,15,16)/p-1/t10-/m0/s1

Upstream product

• 53755-22-9 (22E)-24-Methylergosta-5,22-dien-3β-ol 
• 53755-20-7 (5β,6α,22E)-3',6-Dihydrocyclopropa[5,6]stigmast-22-en-3β-ol 
• 53755-19-4 (8α)-3',7β-Dihydrocyclopropa[7,8]-5α-cholestan-3-one 
• 5375-51-9 N-[(E)-(5-bromo-2,4-dimethoxyphenyl)methylidene]-3-chloro-2-methylaniline 
• 53755-18-3 (22E)-3',7β-Dihydrocycloprop[7,8]-5α-ergost-22-en-3-one 
• 53755-13-8 23-[2-Methyl-1-(1-methylethyl)cyclopropyl]-24-nor-5α-cholane 
• 53755-09-2 (24E)-Stigmasta-4,24(28)-dien-3-one 
• 5375-50-8 2-(3-chloro-2-methylphenyl)-1H-isoindole-1,3(2H)-dione 
• 53755-04-7 Phaseolic acid 
• 53755-03-6 clovamide 
• 53755-02-5 N-[3’,4’-Dihydroxy-(E)-cinnamoyl]-3-hydroxy-L-tyrosine 
• 53755-01-4 (22E)-5α-Stigmasta-9(11),22-dien-3β-ol 
• 5375-49-5 Methylcarbamic acid 1,2-dihydro-1,2-dihydroxynaphthalen-5-yl ester 
• 53754-71-5 1,1-dimethyl-3,5-dimethylenepiperidinium chloride 

Downstream Products

• 53755-39-8 (8α)-3',7β-Dihydrocyclopropa[7,8]-5α-cholestan-3β-ol 
• 53755-40-1 (5β,22E)-3',6α-Dihydrocyclopropa[5,6]stigmast-22-en-3-one 
• 53755-57-0 2-(ethoxymethyl)-1,4-dihydroxyanthracene-9,10-dione 
• 53755-58-1 Drupanin 
• 53755-73-0 (4S,22S)-C(14a)-Homo-27-norgammacer-14-ene-3β,21α,23,29-tetrol 
• 53755-76-3 (4S)-C(14a)-Homo-27-norgammacer-14-ene-3α,20β,21β,23-tetrol 
• 53755-77-4 (4R)-3β,21β-Dihydroxy-C(14a)-homo-27-norgammacer-14-en-23-oic acid 
• 53756-31-3 Methyl α-D-threo-2-pentulofuranoside 
• 53756-32-4 Methyl β-D-threo-2-pentulofuranoside 
• 5375-63-3 1,2,3,4-Tetrahydro-4-[2-[(1,2-dicarboxyethyl)imino]ethylidene]pyridine-2,6-dicarboxylic acid 
• 53756-33-5 methyl beta-L-ribulofuranoside 
• 53756-34-6 methyl alpha-L-ribulofuranoside 
• 5375-64-4 1,2,3,4-Tetrahydro-4-[2-[[2-(3,4-dihydroxyphenyl)ethyl]imino]ethylidene]pyridine-2,6-dicarboxylic acid 
• 53756-71-1 1-(9-phenanthryl)pyrrolidine 

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