2-Azabicyclo[2.2.1]heptane-3-carboxylicacid,methylester,(1S,3R,4R)-(9CI)

Base Information

• Chemical Name: 2-Azabicyclo[2.2.1]heptane-3-carboxylicacid,methylester,(1S,3R,4R)-(9CI)
• CAS No.: 297143-31-8
• Molecular Formula: C8H13NO2
• Molecular Weight: 155.19400
• Mol file: 297143-31-8.mol

Synonyms:2-Azabicyclo[2.2.1]heptane-3-carboxylicacid,methylester,(1S,3R,4R)-;(1S,3R,4R)-2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid methyl ester;

Chemical Property of 2-Azabicyclo[2.2.1]heptane-3-carboxylicacid,methylester,(1S,3R,4R)-(9CI)

Chemical Property:

• PSA: 38.33000
• LogP: 0.62870

Purity/Quality:

97% ^*data from raw suppliers

(1S,3R,4R)-2-Aza-bicyclo[2.2.1]heptane-3-carboxylicacidmethylester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Azabicyclo[2.2.1]heptane-3-carboxylicacid,methylester,(1S,3R,4R)-(9CI)

There total 3 articles about 2-Azabicyclo[2.2.1]heptane-3-carboxylicacid,methylester,(1S,3R,4R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,3R,4S)-2-[(1S)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid methyl ester (130195-74-3) → (1S,3R,4R)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid methyl ester (297143-31-8,220093-41-4)

Guidance literature:

With hydrogen;

DOI:10.1016/S0022-328X(00)00025-5

Reference yield:

(1S,3R,4R)-2-Aza-bicyclo[2.2.1]heptane-2,3-dicarboxylic acid 2-tert-butyl ester 3-methyl ester → (1S,3R,4R)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid methyl ester (297143-31-8,220093-41-4)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 3h;

Reference yield:

cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) → (1S,3R,4R)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid methyl ester (297143-31-8,220093-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂

With hydrogen; 1: aza-Diels-Alder reaction;

DOI:10.1016/S0022-328X(00)00025-5

upstream raw materials:

(1R,3R,4S)-2-[(1S)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid methyl ester

cyclopenta-1,3-diene

Downstream raw materials:

(1S,3R,4R)-2-benzyl-2-azabicyclo[2.2.1]heptane-3-carboxylic acid methyl ester

(1S,3R,4R)-2-(p-tert-butylphenylsulphonyl)-2-aza-bicyclo[2.2.1]heptane-3-caboxylic acid

(1S,3R,4R)-3-(toluene-4-sulfonyloxymethyl)-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

(1S,3R,4R)-3-benzylsulfanylmethyl-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

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