1-(4-Methoxyphenyl)cyclobutanecarbonitrile

Base Information

• Chemical Name: 1-(4-Methoxyphenyl)cyclobutanecarbonitrile
• CAS No.: 29786-45-6
• Molecular Formula: C12H13NO
• Molecular Weight: 187.241
• Hs Code.: 2926909090
• Mol file: 29786-45-6.mol

Synonyms:1-(p-methoxyphenyl)cyclobutanecarbonitrile;1-(4-methoxyphenyl)cyclobutane carbonitrile;

Chemical Property of 1-(4-Methoxyphenyl)cyclobutanecarbonitrile

Chemical Property:

• PSA: 33.02000
• LogP: 2.64048

Purity/Quality:

99%, ^*data from raw suppliers

1-(4-Methoxyphenyl)cyclobutanecarbonitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Methoxyphenyl)cyclobutanecarbonitrile

There total 2 articles about 1-(4-Methoxyphenyl)cyclobutanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.5%

→ 1-(4-methoxyphenyl)cyclobutane-1-carbonitrile (29786-45-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at -10 - 0 ℃; for 1h; Inert atmosphere;

In N,N-dimethyl-formamide; mineral oil; at -10 - 10 ℃;

Reference yield: 41.0%

p-methoxybenzylnitrile (104-47-2) + 1,3-dibromo-propane (109-64-8) → 1-(4-methoxyphenyl)cyclobutane-1-carbonitrile (29786-45-6)

Guidance literature:

With sodium hydride; sodium iodide; In diethyl ether; dimethyl sulfoxide; mineral oil; at 20 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201600305

Reference yield: 93.8%

1-(4-methoxyphenyl)cyclobutane-1-carbonitrile (29786-45-6) → 1-(4-methoxyphenyl)cyclobutane-1-carboxamide (29786-55-8)

Guidance literature:

With tetrabutylammomium bromide; dihydrogen peroxide; sodium hydroxide; In methanol; at 20 ℃; for 17h;

upstream raw materials:

p-methoxybenzylnitrile

1,3-dibromo-propane

Downstream raw materials:

1-(4-methoxyphenyl)cyclobutane-1-carboxamide

1-(4-methoxy-phenyl)-cyclobutanecarboxylic acid

(2S,5R,6R)-6-{[1-(4-Methoxy-phenyl)-cyclobutanecarbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

<1-(p-Methoxyphenyl)-cyclobutyl>-carbonylisocyanat

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