9-Phenanthrenecarboxylic acid, 2,3,6-trimethoxy-

Base Information

• Chemical Name: 9-Phenanthrenecarboxylic acid, 2,3,6-trimethoxy-
• CAS No.: 30062-39-6
• Molecular Formula: C18H16O5
• Molecular Weight: 312.322
• Mol file: 30062-39-6.mol

Synonyms:

Chemical Property of 9-Phenanthrenecarboxylic acid, 2,3,6-trimethoxy-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-Phenanthrenecarboxylic acid, 2,3,6-trimethoxy-

There total 1 articles about 9-Phenanthrenecarboxylic acid, 2,3,6-trimethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

(E)-2-(4-methoxyphenyl)-3-(2-amino-4,5-dimethoxyphenyl)cinnamic acid (68742-17-6) → 2,3,6-trimethoxyphenanthrene-9-carboxylic acid (30062-39-6) + (E)-3-(2-Iodo-4,5-dimethoxy-phenyl)-2-(4-methoxy-phenyl)-acrylic acid

Guidance literature:

DOI:10.1021/jo00171a014

Reference yield: 58.0%

2,3,6-trimethoxyphenanthrene-9-carboxylic acid (30062-39-6) + methoxybenzene (100-66-3) → (4-methoxyphenyl)-(2,3,6-trimethoxyphenanthren-9-yl)methanone (876053-90-6)

Guidance literature:

With PPA; at 100 ℃; for 2h;

DOI:10.1016/j.bmc.2005.10.002

Reference yield:

2,3,6-trimethoxyphenanthrene-9-carboxylic acid (30062-39-6) → 10-(1-Cyclohexylmethyl-pyrrolidin-2-ylmethyl)-2,3,6-trimethoxy-phenanthrene-9-carboxylic acid methyl ester (87166-91-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) oxalyl chloride / 1) THF, 0.5 h, reflux; 2) THF

3: Zn-Cu couple, 10percent KOH / H₂O; pyridine / 13 h / Heating

4: standard esterification

5: 26 percent / hydrogen / PtO₂ / acetic acid / 16 h / Ambient temperature

With potassium hydroxide; oxalyl dichloride; hydrogen; copper; zinc; platinum(IV) oxide; In pyridine; water; acetic acid;

DOI:10.1016/S0040-4020(01)91913-1

upstream raw materials:

(E)-2-(4-methoxyphenyl)-3-(2-amino-4,5-dimethoxyphenyl)cinnamic acid

Downstream raw materials:

(4-methoxyphenyl)-(2,3,6-trimethoxyphenanthren-9-yl)methanone

(4-methoxyphenyl)-(2,3,6-trimethoxyphenanthren-9-yl)methanol

2-[(4-methoxyphenyl)-(2,3,6-trimethoxyphenanthren-9-yl)methyl]phenol

4-[(4-methoxyphenyl)-(2,3,6-trimethoxyphenanthren-9-yl)methyl]phenol