Welcome to LookChem.com Sign In|Join Free
  • or


Post Buying Request

100-66-3 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
High purity Anisole supplier CAS: 100-66-3
Cas No: 100-66-3
USD $ 30.0-50.0 / Gram 100 Gram 50000 Metric Ton/Month WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
High quality Anisole supplier in China
Cas No: 100-66-3
No Data 1 Kilogram 2000 Metric Ton/Year Simagchem Corporation Contact Supplier
Cas No: 100-66-3
No Data 200 Kilogram 300 Metric Ton/Year Jiaxing TriView Biochemical Products Co., Ltd. Contact Supplier
Anisole Manufacturer/High quality/Best price/In stock
Cas No: 100-66-3
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Cas No: 100-66-3
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Cas No: 100-66-3
USD $ 2.0-3.0 / Kilogram 1 Kilogram 100 Metric Ton/Week EAST CHEMSOURCES LIMITED Contact Supplier
Amadis Chemical offer CAS#100-66-3;CAT#A800255
Cas No: 100-66-3
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Cas No: 100-66-3
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Anisole CAS:100-66-3
Cas No: 100-66-3
USD $ 1.0-2.0 / Metric Ton 5 Metric Ton 1000 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
TIANFU-CHEM CAS NO.100-66-3 Anisole
Cas No: 100-66-3
No Data 1 Kilogram 1 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier

100-66-3 Usage

Storage feature

complete package, with care, warehouse ventilation, away from open flame, heat, and stored separately from oxidants

Chemical Properties

Clear straw colored liquid

Chemical properties

It is a colorless liquid, with an aromatic odor, insoluble in water, soluble in alcohol, ether.

Stimulus data

Skin-rabbit 500 mg/24 hours moderate

Air & Water Reactions

Flammable. Ethers tend to form unstable peroxides when exposed to oxygen. Ethyl, isobutyl, ethyl tert-butyl, and ethyl tert-pentyl ether are particularly hazardous in this respect. Ether peroxides can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Insoluble in water


LD50 3700 mg/kg (rat, oral).

Toxicity grading

Moderate toxicity


A biochemical for proteomics research.

Occupational standards

STEL 10 mg/m3

Purification Methods

Shake anisole with half its volume of 2M NaOH, and the emulsion is allowed to separate. Repeat three times, then wash twice with water, dry over CaCl2, filter, dry over sodium wire and finally distil it from fresh sodium under N2 using a Dean-Stark trap (samples in the trap being rejected until free from turbidity) [Caldin et al. J Chem Soc, Faraday Trans 1 72 1856 1976]. Alternatively dry it with CaSO4 or CaCl2, or by refluxing with sodium or BaO with crystalline FeSO4 or by passage through an alumina column. Traces of phenols are removed by prior shaking with 2M NaOH, followed by washing with water. It has been be purified by zone refining. [Beilstein 6 IV 548.]

Limited use

FEMA (mg/kg): Soft drinks 9.0, cold 16, confectionery51, bakery 34.
limited in moderation (FDA§172.515,2000).


1. GB2760-1996 stipulates it as allowable usable spices in food. It is mainly used for the preparation of vanilla, fennel and beer flavor.
2. It is used for analyzing the reagents, solvents, and used for preparing perfumery and enteral pesticides.
3. It is used for the production of perfumes, dyes, pharmaceuticals, pesticides, also used as a solvent.
4. It is used in organic synthesis, also used as solvents, perfume and insect repellent.
5. It is used as solvents for recrystallization, fillers of thermostat, and used for measuring refractive index, as spices and organic synthesis intermediates.

Acute toxicity

Oral-rat LD50: 3700 mg/kg. Oral-Mouse LD50: 2800 mg/kg

Product Features

Anisole, also known as anise ether, methoxybenzene methyl phenyl ether, is a colorless liquid with an odor of anise, sweet, naturally present in the tarragon oil, insoluble in water, soluble in alcohol, ether, acetone, soluble in benzene. It irritates the eyes and mucous membranes. It is obtained originally from distilled methyl salicylate or methoxybenzoate, is now mainly produced through the reaction of methylating agent of dimethyl sulfate with phenol in alkaline aqueous solution. Anisole is prone to start Electrophilic substitution reaction in aromatic nucleus, and condensed with formaldehyde to produce viscous oil or resin material, reacts with phosphorus trichloride to produce chlorine anisole and a small amount of o-chloro product, reacts with thionyl chloride to produce 2,4,6-trichloroanisole. In addition, anisole is heated to react with hydrobromic or hydroiodic, carbon-oxygen bond cleaves, phenol and halogenated methane is produced, which is an important method for determining methoxy group of benzene ring.
The above information is edited by the chemicalbook of Yan Yanyong.

Reactivity Profile

Ethers, such as Anisole can act as bases. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.


ChEBI: A monomethoxybenzene that is benzene substituted by a methoxy group.

Flammability hazard characteristics

In case of fire, high temperature, strong oxidants, it is combustible. Burning discharges irritative smoke.

General Description

A clear straw-colored liquid with an aromatic odor. Insoluble in water and the same density as water. Vapors heavier than air. Flash point 125°F. Boiling point 307°F. Moderately toxic by ingestion. A skin irritant. Used to make perfumes, flavorings and as a solvent.


In perfumery, in organic syntheses.

Production method

It is produced through the reaction of methylating agent of dimethyl sulfate with phenol in alkaline aqueous solution. Phenol was mixed with sodium hydroxide solution, dimethyl sulfate was slowly added at below 10 ℃. And then heat to 40 ℃, reflux for 18h, then stand for separation of the oil and dried with anhydrous calcium chloride, vacuum distillation to obtain anisole.
It is derived by introducing the methyl chloride into the sodium phenol of liquid ammonia to react.
It is generated from heating phenol and methanol.
It is obtained from the reaction of phenol with dimethyl sulfate in the presence of sodium hydroxide.

Health Hazard

Inhalation or contact with material may irritate or burn skin and eyes. Fire may produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Extinguishing agents

Foam, carbon dioxide, dry sandy, soil


Flammable liquid

100-66-3 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma-Aldrich (96109)  Anisole  analytical standard 100-66-3 96109-10ML-F 1,068.21CNY Detail
Sigma-Aldrich (96109)  Anisole  analytical standard 100-66-3 96109-5ML-F 589.68CNY Detail
USP (1037011)  Anisole  United States Pharmacopeia (USP) Reference Standard 100-66-3 1037011-3X1.2ML 4,647.24CNY Detail
Sigma-Aldrich (PHR1212)  Anisole  pharmaceutical secondary standard; traceable to USP 100-66-3 PHR1212-3X1.2ML 732.19CNY Detail
Sigma-Aldrich (123226)  Anisole  ReagentPlus®, 99% 100-66-3 123226-18L-CS 12,273.30CNY Detail
Sigma-Aldrich (123226)  Anisole  ReagentPlus®, 99% 100-66-3 123226-2.5L 2,183.22CNY Detail
Sigma-Aldrich (123226)  Anisole  ReagentPlus®, 99% 100-66-3 123226-1L 1,432.08CNY Detail
Sigma-Aldrich (123226)  Anisole  ReagentPlus®, 99% 100-66-3 123226-250ML 691.47CNY Detail
Sigma-Aldrich (296295)  Anisole  anhydrous, 99.7% 100-66-3 296295-2L 2,021.76CNY Detail
Sigma-Aldrich (296295)  Anisole  anhydrous, 99.7% 100-66-3 296295-1L 1,432.08CNY Detail
Sigma-Aldrich (296295)  Anisole  anhydrous, 99.7% 100-66-3 296295-100ML 1,060.02CNY Detail
Alfa Aesar (A12997)  Anisole, 99%    100-66-3 10000g 2213.0CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name anisole

1.2 Other means of identification

Product number -
Other names Anizol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100-66-3 SDS

100-66-3Related news

A study of the hydrodeoxygenation of Anisole (cas 100-66-3) over Re-MoOx/TiO2 catalyst07/26/2019

A well-characterized Re-MoOx/TiO2 catalyst was used to investigate the reaction sequence involved during the hydrodeoxygenation of anisole in a batch reactor by varying the initial anisole concentration in the reactant mixture (0.182–0.382 mol L−1 corresponding to 2.6–5.4 wt.%), the reaction t...detailed

Flame structure of laminar premixed Anisole (cas 100-66-3) flames investigated by photoionization mass spectrometry and photoelectron spectroscopy07/25/2019

Two laminar, premixed, fuel-rich flames fueled by anisole-oxygen-argon mixtures with the same cold gas velocity and pressure were investigated by molecular-beam mass spectrometry at two synchrotron sources where tunable vacuum-ultraviolet radiation enables isomer-resolved photoionization. Decomp...detailed

Electrochemical synthesis of Anisole (cas 100-66-3) on platinum anode surface: Experiment and first-principle study07/24/2019

The anisole is synthesized by electrolyzing of phenol (or sodium phenate) and tetramethylammonium chloride (TMAC). The production forms on the Pt anode surface and not in the solution. There are adequate supplies of methyl radicals in all solutions. The phenoxyl radical is difficult to form in p...detailed

Deoxygenation in Anisole (cas 100-66-3) decomposition over bimetallic catalysts supported on HZSM-507/22/2019

This work investigated the deoxygenation reaction in anisole decomposition over HZSM-5 (HZ(25)) zeolite supported bimetallic catalysts to produce benzene, toluene and xylene (BTX). Experiments were performed in order to evaluate the synergistic effect between the two active metals with the focus...detailed

Experimental and kinetic modeling investigation on Anisole (cas 100-66-3) pyrolysis: Implications on phenoxy and cyclopentadienyl chemistry07/20/2019

In this work, the flow reactor pyrolysis of anisole was studied at pressures of 0.04 and 1 atm and temperatures from 850 to 1160 K. Comprehensive speciation was achieved using synchrotron vacuum ultraviolet photoionization mass spectrometry (SVUV-PIMS). A detailed kinetic model for anisole combu...detailed

Testing of Anisole (cas 100-66-3) and methyl acetate as additives to diesel and biodiesel fuels in a compression ignition engine07/21/2019

This paper investigates the effects of anisole and methyl acetate (as fuel additives) on the performance and emission characteristics of a compression-ignition (i.e., diesel) engine. Anisole and methyl acetate can be obtained from methylation of phenol and acetic acid, respectively. Phenol and a...detailed

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields