Morpholine, 4-(1-phenyl-1-propenyl)-, (E)-

Base Information

• Chemical Name: Morpholine, 4-(1-phenyl-1-propenyl)-, (E)-
• CAS No.: 30085-70-2
• Molecular Formula: C13H17NO
• Molecular Weight: 203.284
• Mol file: 30085-70-2.mol

Synonyms:

Chemical Property of Morpholine, 4-(1-phenyl-1-propenyl)-, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Morpholine, 4-(1-phenyl-1-propenyl)-, (E)-

There total 5 articles about Morpholine, 4-(1-phenyl-1-propenyl)-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

morpholine (110-91-8,99108-56-2) + 1-phenyl-propan-1-one (93-55-0) → [E]-1-morpholino-1-phenyl-1-propene (30085-70-2)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 12h; Heating;

DOI:10.1002/hlca.19930760707

Reference yield: 65.0%

morpholine (110-91-8,99108-56-2) + 1-phenyl-propan-1-one (93-55-0) → 4-(1-phenyl-propenyl)-morpholine (30085-70-2,39655-41-9,66217-92-3)

Guidance literature:

With titanium tetrachloride; In hexane; for 1h; Heating;

Reference yield:

morpholine (110-91-8,99108-56-2) + 1-Phenylprop-1-yne (673-32-5) → 4-(1-phenyl-propenyl)-morpholine (30085-70-2,39655-41-9,66217-92-3) + 2-(4-morpholino)-1-phenylprop-1-ene (4859-64-7)

Guidance literature:

With C₂₇H₃₄AuN₃P⁽¹⁺⁾*CF₃O₃S^(1-); zinc trifluoromethanesulfonate; In toluene; at 110 ℃; regioselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.1c02098

upstream raw materials:

morpholine

1-phenyl-propan-1-one

1-Phenylprop-1-yne

Downstream raw materials:

4-(2-methyl-1,1-dioxo-3-phenyl-1λ⁶-thietan-3-yl)-morpholine

2-Morpholin-4-yl-2-phenyl-3-phenylselanyl-butyronitrile

[1-Morpholin-4-yl-1-phenyl-meth-(Z)-ylidene]-phosphoramidic acid diphenyl ester

diphenyl N-<2-phenyl-1-(4-morpholinyl)propylidene>phosphoramidate

Refernces

• 1、 Jia, Teng,Fan, Shengyu,Li, Fengmian,Ye, Xiaohan,Zhang, Wenke,Song, Zhiguang,Shi, Xiaodong. "Achieving Aliphatic Amine Addition to Arylalkynes via the Lewis Acid Assisted Triazole-Gold (TA-Au) Catalyst System". supporting information. p. 6019 - 6023. Retrieved 2021/08/03.
• 2、 Donohue, Sean R.,Dannals, Robert F.,Halldin, Christer,Pike, Victor W.. "N -(4-cyanotetrahydro-2 H -pyran-4-yl) and N -(1-cyanocyclohexyl) derivatives of 1,5-diarylpyrazole-3-carboxamides showing high affinity for 18 kDa translocator protein and/or cannabinoid receptors". experimental part. p. 2961 - 2970. Retrieved 2011/06/24.