ethyl 1-cyclopropyl-5-hydroxy-2-Methyl-1H-indole-3-carboxylate

Base Information

Chemical Name:ethyl 1-cyclopropyl-5-hydroxy-2-Methyl-1H-indole-3-carboxylate
CAS No.:301173-79-5
Molecular Formula:C15H17NO3
Molecular Weight:259.30000
Hs Code.:
Mol file:301173-79-5.mol

Synonyms:1-Cyclopropyl-5-hydroxy-2-methyl-1H-indole-3-carboxylic acid ethyl ester;

Suppliers and Price of ethyl 1-cyclopropyl-5-hydroxy-2-Methyl-1H-indole-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of ethyl 1-cyclopropyl-5-hydroxy-2-Methyl-1H-indole-3-carboxylate

Chemical Property:

PSA：51.46000
LogP:3.16690

Purity/Quality:: 97-99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 1-cyclopropyl-5-hydroxy-2-Methyl-1H-indole-3-carboxylate

There total 2 articles about ethyl 1-cyclopropyl-5-hydroxy-2-Methyl-1H-indole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 213454-27-4
3-cyclopropylamino-but-2-enoic acid ethyl ester

: 106-51-4
p-benzoquinone

: 301173-79-5
ethyl 1-cyclopropyl-5-hydroxy-2-methylindole-3-carboxylate

Guidance literature:: With acetic acid; at 20 ℃; for 5h; Neat (no solvent);

Reference yield:

: 141-97-9
ethyl acetoacetate

: 301173-79-5
ethyl 1-cyclopropyl-5-hydroxy-2-methylindole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / diethyl ether; water / 17 h / 20 - 40 °C

1.2: pH 8

2.1: 1,2-dichloro-ethane / 8 h / 60 °C / Heating / reflux

With sodium hydroxide; In diethyl ether; water; 1,2-dichloro-ethane;

Reference yield:

: 301173-79-5
ethyl 1-cyclopropyl-5-hydroxy-2-methylindole-3-carboxylate

: ethyl 6-bromo-1-cyclopropyl-4-[(dimethylamino)methyl]-5-hydroxy-2-[(3-trifluoromethylphenyl)thiomethyl]-1H-indole-3-carboxylate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / acetone / 4 h / 20 - 30 °C

2.1: bromine / dibenzoyl peroxide / tetrachloromethane / 5 h / Heating / reflux

3.1: potassium hydroxide / methanol / 2 h / 20 °C

3.2: 6 - 8 h / 20 °C

4.1: acetic acid / water / 6 - 8 h / 50 - 55 °C

4.2: pH 10

5.1: hydrogenchloride / diethyl ether; ethanol; acetone / pH 1 - 2

With pyridine; hydrogenchloride; potassium hydroxide; bromine; acetic acid; dibenzoyl peroxide; In methanol; tetrachloromethane; diethyl ether; ethanol; water; acetone;