3-Oxazolidinecarboxylic acid, 4-[[(2R,4S)-2-(1,1-dimethylethyl)-5-oxo-4-(phenylmethyl)-1,3-dioxolan-4 -yl]hydroxymethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

Base Information

Chemical Name:3-Oxazolidinecarboxylic acid, 4-[[(2R,4S)-2-(1,1-dimethylethyl)-5-oxo-4-(phenylmethyl)-1,3-dioxolan-4 -yl]hydroxymethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-
CAS No.:301180-84-7
Molecular Formula:C25H37NO7
Molecular Weight:463.571
Hs Code.:
Mol file:301180-84-7.mol

3-Oxazolidinecarboxylic acid,
4-[[(2R,4S)-2-(1,1-dimethylethyl)-5-oxo-4-(phenylmethyl)-1,3-dioxolan-4
-yl]hydroxymethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Oxazolidinecarboxylic acid, 4-[[(2R,4S)-2-(1,1-dimethylethyl)-5-oxo-4-(phenylmethyl)-1,3-dioxolan-4 -yl]hydroxymethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

Chemical Property:

Purity/Quality:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Oxazolidinecarboxylic acid, 4-[[(2R,4S)-2-(1,1-dimethylethyl)-5-oxo-4-(phenylmethyl)-1,3-dioxolan-4 -yl]hydroxymethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)-

There total 4 articles about 3-Oxazolidinecarboxylic acid, 4-[[(2R,4S)-2-(1,1-dimethylethyl)-5-oxo-4-(phenylmethyl)-1,3-dioxolan-4 -yl]hydroxymethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 102308-32-7
(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 301180-83-6
(2R,5R)-5-Benzyl-2-tert-butyl-[1,3]dioxolan-4-one

: 301180-84-7
4-[(4-benzyl-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/ol006246q DOI:10.1021/ol006246q

Reference yield:

: 828-01-3,7326-19-4,20312-36-1,156-05-8
D-phenyllactic acid

: 301180-84-7
4-[(4-benzyl-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / BF₃*OEt₂ / diethyl ether / 2 h / -20 °C

2: 77 percent / LDA / tetrahydrofuran / 2 h / -78 °C

With boron trifluoride diethyl etherate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; 1: Cyclization / 2: Condensation;
DOI:10.1021/ol006246q DOI:10.1021/ol006246q

Reference yield:

: 630-19-3
pivalaldehyde

: 301180-84-7
4-[(4-benzyl-2-tert-butyl-5-oxo-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / BF₃*OEt₂ / diethyl ether / 2 h / -20 °C

2: 77 percent / LDA / tetrahydrofuran / 2 h / -78 °C

With boron trifluoride diethyl etherate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; 1: Cyclization / 2: Condensation;
DOI:10.1021/ol006246q