Phenyl(1-phenyl-1H-imidazol-2-yl)methanone

Base Information

• Chemical Name: Phenyl(1-phenyl-1H-imidazol-2-yl)methanone
• CAS No.: 30148-22-2
• Molecular Formula: C16H12N2O
• Molecular Weight: 248.284
• DSSTox Substance ID: DTXSID901267266
• Mol file: 30148-22-2.mol

Synonyms:Phenyl(1-phenyl-1H-imidazol-2-yl)methanone;DTXSID901267266;30148-22-2

Chemical Property of Phenyl(1-phenyl-1H-imidazol-2-yl)methanone

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 248.094963011
• Heavy Atom Count: 19
• Complexity: 306

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C2=NC=CN2C3=CC=CC=C3

Technology Process of Phenyl(1-phenyl-1H-imidazol-2-yl)methanone

There total 2 articles about Phenyl(1-phenyl-1H-imidazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-phenylimidazole (7164-98-9) + benzoyl chloride (98-88-4) → phenyl(1-phenyl-1H-imidazol-2-yl)methanone (30148-22-2)

Guidance literature:

With triethylamine; In acetonitrile; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c6cc04397f

Reference yield:

→ phenyl(1-phenyl-1H-imidazol-2-yl)methanone (30148-22-2)

Guidance literature:

1-Phenylimidazol,Benzoylierung;

Reference yield: 92.0%

diphenyl acetylene (501-65-5) + phenyl(1-phenyl-1H-imidazol-2-yl)methanone (30148-22-2) → (4,5-diphenylimidazo[1,5-a]quinolin-1-yl)(phenyl)methanone (1428368-40-4)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; In toluene; at 110 ℃; for 36h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol400537b

upstream raw materials:

1-phenylimidazole

benzoyl chloride

Downstream raw materials:

(4,5-diphenylimidazo[1,5-a]quinolin-1-yl)(phenyl)methanone