3-(4-Nitro-phenyl)-5-methyl-isoxazole

Base Information

• Chemical Name: 3-(4-Nitro-phenyl)-5-methyl-isoxazole
• CAS No.: 30213-79-7
• Molecular Formula: C10H8N2O3
• Molecular Weight: 204.185
• Mol file: 30213-79-7.mol

Synonyms:3-(4-Nitro-phenyl)-5-methyl-isoxazole;5-Methyl-3-p-nitro-phenyl-isoxazol;

Chemical Property of 3-(4-Nitro-phenyl)-5-methyl-isoxazole

Chemical Property:

• PSA: 71.85000
• LogP: 3.08140

Purity/Quality:

99% ^*data from raw suppliers

5-Methyl-3-(4-nitrophenyl)isoxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Nitro-phenyl)-5-methyl-isoxazole

There total 12 articles about 3-(4-Nitro-phenyl)-5-methyl-isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-(4-nitrophenyl)-1-methyl-3-oxo-1-propenamine → 3-(4-nitro-phenyl)-5-methylisoxazole (30213-79-7)

Guidance literature:

With Montmorillonite K₁₀; hydroxylamine hydrochloride; for 3h; ultrasonication;

DOI:10.1002/jhet.5570360229

Reference yield: 91.0%

4-(p-nitrophenyl)-3-butene-2-one (946-49-6,3490-37-7,30625-98-0) → 3-(4-nitro-phenyl)-5-methylisoxazole (30213-79-7)

Guidance literature:

4-(p-nitrophenyl)-3-butene-2-one; With p-toluenesulfonylhydroxylamine; potassium carbonate; In methanol; water; at 40 ℃; for 24h;

With potassium carbonate; In methanol; water; at 60 ℃; for 10h; regiospecific reaction;

DOI:10.1021/ol901626n

Reference yield: 78.0%

5-(bromomethyl)-3-(4-nitrophenyl)-4,5-dihydroisoxazole (1287686-47-8) → 3-(4-nitro-phenyl)-5-methylisoxazole (30213-79-7)

Guidance literature:

With 2,2,2-trifluoroethanol; sodium hydride; In tetrahydrofuran; at 0 - 60 ℃;

DOI:10.1021/jf200395g

upstream raw materials:

<3-(4-Nitrophenyl)-5-isoxazolylmethyl>triphenylphosphonium-chlorid

2-nitropropene

4-nitrobenzohydroximoyl chloride

methyllithium

Downstream raw materials:

4-(5-methylisoxazol-3-yl)aniline

2,6-difluoro-N-(4-(5-methylisoxazol-3-yl)phenylcarbaphenylcarbamoyl)benzamide