7-Chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one

Base Information

Chemical Name:7-Chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
CAS No.:3023-44-7
Molecular Formula:C16H13ClN2O2
Molecular Weight:300.744
Hs Code.:
ChEMBL ID:CHEMBL315461
DSSTox Substance ID:DTXSID30877949
Nikkaji Number:J343.771J
Mol file:3023-44-7.mol

Synonyms:3023-44-7;CHEMBL315461;DTXSID30877949;1,4-BENZODIAZP-2-ON,5(2MEOPH)7CL;7-Chloro-1,3-dihydro-5-(2-methoxyphenyl)-2H-1,4-benzodiazepine-2-one

Suppliers and Price of 7-Chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 7-Chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one

Chemical Property:

PSA：50.69000
LogP:2.71170
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:300.0665554
Heavy Atom Count:21
Complexity:427

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1C2=NCC(=O)NC3=C2C=C(C=C3)Cl

Technology Process of 7-Chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one

There total 7 articles about 7-Chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 115435-82-0
5-chloro-2'-methoxy-2-(phthalimidoacetamido)benzophenone

: 3023-44-7
7-chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one

Guidance literature:: With hydrazine hydrate; In methanol;

Reference yield:

: 7035-03-2
2-methoxy-benzeneacetonitrile

: 3023-44-7
7-chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 27 percent / 79percent KOH / benzene; methanol / 1.) 25-32 deg C, 1.5 h, 2.) R_.T_., 3 h.

2: 75 percent / Fe / ethanol; H₂O; acetic acid

3: 99 percent / CHCl₃ / Heating

4: 90 percent / 18percent N₂H₄ / methanol

With potassium hydroxide; iron; hydrazine hydrate; In methanol; ethanol; chloroform; water; acetic acid; benzene;

Reference yield:

: 612-16-8
(2-methoxyphenyl)methanol

: 3023-44-7
7-chloro-5-(2-methoxyphenyl)-1,3-dihydro-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / SOCl₂ / benzene / 1.) 2 deg C, 100 min, 2.) 45-50 deg C, 2 h.

2: 97 percent / dimethylsulfoxide / 3 h / 35 - 45 °C

3: 27 percent / 79percent KOH / benzene; methanol / 1.) 25-32 deg C, 1.5 h, 2.) R_.T_., 3 h.

4: 75 percent / Fe / ethanol; H₂O; acetic acid

5: 99 percent / CHCl₃ / Heating

6: 90 percent / 18percent N₂H₄ / methanol

With potassium hydroxide; thionyl chloride; iron; hydrazine hydrate; In methanol; ethanol; chloroform; water; acetic acid; dimethyl sulfoxide; benzene;