7035-03-2

Basic information

• Product Name: 2-Methoxyphenylacetonitrile
• Synonyms: (o-Methoxyphenyl)acetonitrile;Benzeneacetonitrile, 2-methoxy-;o-Methoxyphenylacetonitrile;O-ANISYL CYANIDE;O-METHOXYBENZYL CYANIDE;2-METHOXYBENZYL CYANIDE;(2-METHOXYPHENYL)ACETONITRILE;2-Methoxyphenyl Acetonitrile 2-Methoxybenzyl Cyanide o-Methoxybenzyl Cyanide
• CAS NO: 7035-03-2
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• EINECS: 230-314-5
• Product Categories: Aromatic Nitriles
• Mol File: 7035-03-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: 65-67 °C(lit.)
• Boiling Point: 143 °C15 mm Hg(lit.)
• Flash Point: 129°C
• Appearance: white to slightly brown crystalline powder
• Density: 1.1135 (rough estimate)
• Vapor Pressure: 0.00767mmHg at 25°C
• Refractive Index: 1.5309 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: 0.01g/l
• BRN: 2087748
• CAS DataBase Reference: 2-Methoxyphenylacetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxyphenylacetonitrile(7035-03-2)
• EPA Substance Registry System: 2-Methoxyphenylacetonitrile(7035-03-2)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-24/25-36/37-36-26
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 7035-03-2(Hazardous Substances Data)

Usage

Uses

2-Methoxyphenylacetonitrile was used in the synthesis of 2-(1-cyano-1-(2-methoxy)phenyl)methylidene-3-phenylthiazolidine-4,5-dione.

InChI:InChI=1/C9H9NO/c1-11-9-5-3-2-4-8(9)6-7-10/h2-5H,6H2,1H3

Upstream product

• 52289-93-7 o-Methoxybenzyl bromide 
• 151-50-8 potassium cyanide 
• 7035-02-1 o-Methoxybenzyl chloride 
• 2045-79-6 o-methoxy-2-phenylethylamine 
• 33390-80-6 2-(2-methoxyphenyl)acetamide 
• 557-21-1 zinc(II) cyanide 
• 578-57-4 2-bromoanisole 
• 105-56-6 ethyl 2-cyanoacetate 
• 766-51-8 2-Chloroanisole 
• 19350-70-0 2-methoxybenzaldehyde p-toluenesulfonylhydrazone 
• 333-20-0 potassium thioacyanate 
• 33567-59-8 (2-methoxy-phenyl)-acetaldehyde 
• 100-66-3 methoxybenzene 
• 75-05-8 acetonitrile 

Downstream Products

• 110394-05-3 1-(6-hydroxy-2,3-dihydro-benzofuran-5-yl)-2-(2-methoxy-phenyl)-ethanone 
• 116854-95-6 2-(2-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)ethanone 
• 16469-98-0 6-(2-methoxy-phenyl)-pteridine-2,4,7-triamine 
• 6056-23-1 ethyl (2-methoxyphenyl)acetate 
• 110252-77-2 2-(2-methoxy-phenyl)-3-oxo-3-o-tolyl-propionitrile 
• 789493-47-6 2-hydroxy-4,6,2'-trimethoxy-3-methyl-deoxybenzoin 
• 132593-11-4 3-(2,4-dimethoxy-phenyl)-2-(2-methoxy-phenyl)-3-oxo-propionitrile 
• 93316-18-8 2,3-bis-(2-methoxy-phenyl)-3-oxo-propionitrile 
• 144061-61-0 (2-methoxy-phenyl)-[2]pyridyl-acetonitrile 
• 93-25-4 2-methoxyphenylacetic acid 
• 62115-71-3 2-(2-methoxyphenyl)propanenitrile 
• 856974-25-9 5-(2-methoxy-phenyl)-pyrimidin-4-ylamine 
• 59907-33-4 (2-methoxy-phenethyl)-dimethyl-amine 
• 408510-18-9 4-(2-methoxy-phenyl)-1-methyl-piperidine-4-carbonitrile 

Relevant articles and documents

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Nickel-Catalyzed Deaminative Cyanation: Nitriles and One-Carbon Homologation from Alkyl Amines

A nickel-catalyzed deaminative cyanation of Katritzky pyridinium salts has been developed. When it is coupled with formation of the pyridinium salt from primary amines, this method enables alkyl amines to be converted to alkyl nitriles. A less toxic cyanide reagent, Zn(CN)2, is utilized, and diverse functional groups and heterocycles are tolerated. The method also enables a one-carbon homologation of alkyl amines via reduction of the nitrile products, in addition to many other potential transformations of the versatile nitrile group.

Copper-Catalyzed Cyanation of N-Tosylhydrazones with Thiocyanate Salt as the "cN" Source

A novel protocol for the synthesis of α-aryl nitriles has been successfully achieved via a copper-catalyzed cyanation of N-tosylhydrazones employing thiocyanate as the source of cyanide. The features of this method include a convenient operation, readily available substrates, low-toxicity thiocyanate salts, and a broad substrate scope.