N-acetylsuccinimide

Base Information

• Chemical Name: N-acetylsuccinimide
• CAS No.: 3027-06-3
• Molecular Formula: C6H7NO3
• Molecular Weight: 141.126
• Hs Code.: 2925190090
• DSSTox Substance ID: DTXSID40466429
• Nikkaji Number: J1.703.425A
• Wikidata: Q82292991
• Mol file: 3027-06-3.mol

Synonyms:N-acetylsuccinimide;3027-06-3;1-acetylpyrrolidine-2,5-dione;N-ACETYL SUCCINIMIDE;2,5-Pyrrolidinedione, 1-acetyl-;SCHEMBL887169;DTXSID40466429;RHLBOBPOIZROJX-UHFFFAOYSA-N;AKOS006281472;AS-60423

Chemical Property of N-acetylsuccinimide

Chemical Property:

• PSA: 54.45000
• LogP: -0.38020
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 141.042593085
• Heavy Atom Count: 10
• Complexity: 193

Purity/Quality:

98%Min ^*data from raw suppliers

N-ACETYL SUCCINIMIDE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N1C(=O)CCC1=O

Technology Process of N-acetylsuccinimide

There total 3 articles about N-acetylsuccinimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorophenyl acetate (876-27-7) + succinimide anion (28627-67-0) → 1-acetylpyrrolidine-2,5-dione (3027-06-3) + 4-chlorophenolate (24573-38-4)

Guidance literature:

In water; at 30 ℃; Rate constant;

DOI:10.1021/jo00140a020

Reference yield:

3-nitrophenyl acetate (1523-06-4) + succinimide anion (28627-67-0) → 1-acetylpyrrolidine-2,5-dione (3027-06-3) + 3-nitrophenolate anion (16554-54-4)

Guidance literature:

In water; at 30 ℃; Rate constant;

DOI:10.1021/jo00140a020

Reference yield:

succinimide anion (28627-67-0) + 4-nitrophenol acetate (830-03-5) → 1-acetylpyrrolidine-2,5-dione (3027-06-3) + p-nitrophenolate (14609-74-6)

Guidance literature:

In water; at 30 ℃; Rate constant; pH 9.5, succinimide/succinimide anion buffer, other solvent, addition of var. inorganic chlorides;

DOI:10.1021/jo00140a020

upstream raw materials:

4-chlorophenyl acetate

succinimide anion

3-nitrophenyl acetate

4-nitrophenol acetate

Downstream raw materials:

Ac-Lys(Z)-Lys(Z)-NHMe

N^α-Acetyl-N^ε-benzyloxycarbonyl-L-lysin-methylamid

N-butylacetamide

peracetic acid