3,5,6-Decanetrione, 4-methyl-4-[(phenylmethoxy)methyl]-, (4S)-

Base Information

Chemical Name:3,5,6-Decanetrione, 4-methyl-4-[(phenylmethoxy)methyl]-, (4S)-
CAS No.:303142-75-8
Molecular Formula:C19H26O4
Molecular Weight:318.413
Hs Code.:
Mol file:303142-75-8.mol

Synonyms:

Suppliers and Price of 3,5,6-Decanetrione, 4-methyl-4-[(phenylmethoxy)methyl]-, (4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,5,6-Decanetrione, 4-methyl-4-[(phenylmethoxy)methyl]-, (4S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,5,6-Decanetrione, 4-methyl-4-[(phenylmethoxy)methyl]-, (4S)-

There total 13 articles about 3,5,6-Decanetrione, 4-methyl-4-[(phenylmethoxy)methyl]-, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 303142-84-9
(R)-1-Benzyloxy-2-(2-ethyl-[1,3]dioxolan-2-yl)-2-methyl-octane-3,4-dione

: 303142-75-8
(S)-4-Benzyloxymethyl-4-methyl-decane-3,5,6-trione

Guidance literature:: With toluene-4-sulfonic acid; In acetone; at 60 ℃; for 24h;
DOI:10.1016/S0040-4039(00)00937-0

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 303142-75-8
(S)-4-Benzyloxymethyl-4-methyl-decane-3,5,6-trione

Guidance literature:: Multi-step reaction with 9 steps

1: NaHMDS / tetrahydrofuran / -78 °C

2: 85 percent / LiAlH₄ / tetrahydrofuran / 1.17 h / 0 °C

3: DMSO; (COCl)2; Et₃N / CH₂Cl₂ / -78 °C

4: Mg / tetrahydrofuran / 0.58 h / -45 °C

5: PCC; MS-4A; NaOAc / CH₂Cl₂ / 0.5 h / 20 °C

6: 86 percent / BF₃*OEt₂ / CH₂Cl₂ / 2 h / 0 °C

7: osmium tertoxide; NMO / acetone; 2-methyl-propan-2-ol; H₂O / 120 h

8: TFAA; DMSO; Et₃N / CH₂Cl₂ / 0.83 h / -78 °C

9: 85 percent / TsOH*H₂O / acetone / 24 h / 60 °C

With osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; oxalyl dichloride; boron trifluoride diethyl etherate; sodium acetate; sodium hexamethyldisilazane; toluene-4-sulfonic acid; magnesium; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol; 1: Alkylation / 2: Reduction / 3: Oxidation / 4: Grignard reaction / 5: Oxidation / 6: Etherification / 7: Oxidation / 8: Oxidation / 9: Hydrolysis;
DOI:10.1016/S0040-4039(00)00937-0

Reference yield:

: 97961-67-6
(E)-2-methyloct-2-enoic acid

: 303142-75-8
(S)-4-Benzyloxymethyl-4-methyl-decane-3,5,6-trione

Guidance literature:: Multi-step reaction with 11 steps

1: 93 percent / SOCl₂ / benzene / 3 h / Heating

2: 96 percent / n-BuLi / tetrahydrofuran / -78 °C

3: NaHMDS / tetrahydrofuran / -78 °C

4: 85 percent / LiAlH₄ / tetrahydrofuran / 1.17 h / 0 °C

5: DMSO; (COCl)2; Et₃N / CH₂Cl₂ / -78 °C

6: Mg / tetrahydrofuran / 0.58 h / -45 °C

7: PCC; MS-4A; NaOAc / CH₂Cl₂ / 0.5 h / 20 °C

8: 86 percent / BF₃*OEt₂ / CH₂Cl₂ / 2 h / 0 °C

9: osmium tertoxide; NMO / acetone; 2-methyl-propan-2-ol; H₂O / 120 h

10: TFAA; DMSO; Et₃N / CH₂Cl₂ / 0.83 h / -78 °C

11: 85 percent / TsOH*H₂O / acetone / 24 h / 60 °C

With osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; N-methyl-2-indolinone; oxalyl dichloride; boron trifluoride diethyl etherate; sodium acetate; sodium hexamethyldisilazane; toluene-4-sulfonic acid; magnesium; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol; benzene; 1: Chlorination / 2: Acylation / 3: Alkylation / 4: Reduction / 5: Oxidation / 6: Grignard reaction / 7: Oxidation / 8: Etherification / 9: Oxidation / 10: Oxidation / 11: Hydrolysis;
DOI:10.1016/S0040-4039(00)00937-0