3,4-Octanedione, 2-(2-ethyl-1,3-dioxolan-2-yl)-2-methyl-1-(phenylmethoxy)-, (2R)-

Base Information

Chemical Name:3,4-Octanedione, 2-(2-ethyl-1,3-dioxolan-2-yl)-2-methyl-1-(phenylmethoxy)-, (2R)-
CAS No.:303142-84-9
Molecular Formula:C21H30O5
Molecular Weight:362.466
Hs Code.:
Mol file:303142-84-9.mol

Synonyms:

Suppliers and Price of 3,4-Octanedione, 2-(2-ethyl-1,3-dioxolan-2-yl)-2-methyl-1-(phenylmethoxy)-, (2R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,4-Octanedione, 2-(2-ethyl-1,3-dioxolan-2-yl)-2-methyl-1-(phenylmethoxy)-, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,4-Octanedione, 2-(2-ethyl-1,3-dioxolan-2-yl)-2-methyl-1-(phenylmethoxy)-, (2R)-

There total 12 articles about 3,4-Octanedione, 2-(2-ethyl-1,3-dioxolan-2-yl)-2-methyl-1-(phenylmethoxy)-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 391612-32-1
(R)-1-Benzyloxy-2-(2-ethyl-[1,3]dioxolan-2-yl)-2-methyl-octane-3,4-diol

: 303142-84-9
(R)-1-Benzyloxy-2-(2-ethyl-[1,3]dioxolan-2-yl)-2-methyl-octane-3,4-dione

Guidance literature:: With dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; In dichloromethane; at -78 ℃; for 0.833333h;
DOI:10.1016/S0040-4039(00)00937-0

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 303142-84-9
(R)-1-Benzyloxy-2-(2-ethyl-[1,3]dioxolan-2-yl)-2-methyl-octane-3,4-dione

Guidance literature:: Multi-step reaction with 8 steps

1: NaHMDS / tetrahydrofuran / -78 °C

2: 85 percent / LiAlH₄ / tetrahydrofuran / 1.17 h / 0 °C

3: DMSO; (COCl)2; Et₃N / CH₂Cl₂ / -78 °C

4: Mg / tetrahydrofuran / 0.58 h / -45 °C

5: PCC; MS-4A; NaOAc / CH₂Cl₂ / 0.5 h / 20 °C

6: 86 percent / BF₃*OEt₂ / CH₂Cl₂ / 2 h / 0 °C

7: osmium tertoxide; NMO / acetone; 2-methyl-propan-2-ol; H₂O / 120 h

8: TFAA; DMSO; Et₃N / CH₂Cl₂ / 0.83 h / -78 °C

With osmium(VIII) oxide; lithium aluminium tetrahydride; N-methyl-2-indolinone; oxalyl dichloride; boron trifluoride diethyl etherate; sodium acetate; sodium hexamethyldisilazane; magnesium; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol; 1: Alkylation / 2: Reduction / 3: Oxidation / 4: Grignard reaction / 5: Oxidation / 6: Etherification / 7: Oxidation / 8: Oxidation;
DOI:10.1016/S0040-4039(00)00937-0

Reference yield:

: 97961-67-6
(E)-2-methyloct-2-enoic acid

: 303142-84-9
(R)-1-Benzyloxy-2-(2-ethyl-[1,3]dioxolan-2-yl)-2-methyl-octane-3,4-dione

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / SOCl₂ / benzene / 3 h / Heating

2: 96 percent / n-BuLi / tetrahydrofuran / -78 °C

3: NaHMDS / tetrahydrofuran / -78 °C

4: 85 percent / LiAlH₄ / tetrahydrofuran / 1.17 h / 0 °C

5: DMSO; (COCl)2; Et₃N / CH₂Cl₂ / -78 °C

6: Mg / tetrahydrofuran / 0.58 h / -45 °C

7: PCC; MS-4A; NaOAc / CH₂Cl₂ / 0.5 h / 20 °C

8: 86 percent / BF₃*OEt₂ / CH₂Cl₂ / 2 h / 0 °C

9: osmium tertoxide; NMO / acetone; 2-methyl-propan-2-ol; H₂O / 120 h

10: TFAA; DMSO; Et₃N / CH₂Cl₂ / 0.83 h / -78 °C

With osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; thionyl chloride; N-methyl-2-indolinone; oxalyl dichloride; boron trifluoride diethyl etherate; sodium acetate; sodium hexamethyldisilazane; magnesium; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol; benzene; 1: Chlorination / 2: Acylation / 3: Alkylation / 4: Reduction / 5: Oxidation / 6: Grignard reaction / 7: Oxidation / 8: Etherification / 9: Oxidation / 10: Oxidation;
DOI:10.1016/S0040-4039(00)00937-0