N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-3-phenyl-propionamide

Base Information

Chemical Name:N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-3-phenyl-propionamide
CAS No.:303162-80-3
Molecular Formula:C26H25N3OS
Molecular Weight:427.57
Hs Code.:
DSSTox Substance ID:DTXSID30437704
Wikidata:Q82253254
Pharos Ligand ID:LG1G7UP2M733
ChEMBL ID:CHEMBL194201
Mol file:303162-80-3.mol

Synonyms:CHEMBL194201;303162-80-3;N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-3-phenyl-propionamide;SCHEMBL4260286;DTXSID30437704;BDBM50173633;N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-yl]-3-phenylpropanamide

Suppliers and Price of N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-3-phenyl-propionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-3-phenyl-propionamide

Chemical Property:

XLogP3:5.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:427.17183360
Heavy Atom Count:31
Complexity:567

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)CCC3=CC=CC=C3)C4=CC=CC(=C4)C

Technology Process of N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-3-phenyl-propionamide

There total 5 articles about N-[4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-yl]-3-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 303162-39-2
4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine

: 645-45-4
hydrocinnamic acid chloride

: 303162-80-3
N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-yl]-3-phenylpropionamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jm050165o

Reference yield:

: 303162-37-0
2-(2-tert-butoxycarbonylamino-pyridin-4-yl)-1-(3-methylphenyl)ethanone

: 303162-80-3
N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-yl]-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Br₂; AcOH / 3 h / 80 °C

2: 60 percent / dimethylformamide / 14 h / 20 °C

3: 75 percent / Et₃N / tetrahydrofuran / 1 h / 20 °C

With bromine; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm050165o

Reference yield:

: 2-(2-amino-4-pyridyl)-2-bromo-1-(3-methylphenyl)ethanone hydrobromide

: 303162-80-3
N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-yl]-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / dimethylformamide / 14 h / 20 °C

2: 75 percent / Et₃N / tetrahydrofuran / 1 h / 20 °C

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm050165o