4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-amine

Base Information

Chemical Name:4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-amine
CAS No.:303162-39-2
Molecular Formula:C17H17N3S
Molecular Weight:295.408
Hs Code.:
DSSTox Substance ID:DTXSID50431906
Wikidata:Q82245932
Pharos Ligand ID:5KH1UVJD2BTY
ChEMBL ID:CHEMBL197983
Mol file:303162-39-2.mol

Synonyms:4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-amine;303162-39-2;CHEMBL197983;SCHEMBL3887326;DTXSID50431906;VMHXXKMCQDJJSH-UHFFFAOYSA-N;BDBM50173612;4-[2-ETHYL-4-(3-METHYLPHENYL)-1,3-THIAZOL-5-YL]-2-PYRIDYLAMINE;4-(2-Ethyl-4-m-tolyl-thiazol-5-yl)-pyridin-2-ylamine

Suppliers and Price of 4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-amine

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:295.11431873
Heavy Atom Count:21
Complexity:338

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=NC(=C(S1)C2=CC(=NC=C2)N)C3=CC=CC(=C3)C

Technology Process of 4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-amine

There total 7 articles about 4-[2-Ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 2-(2-amino-4-pyridyl)-2-bromo-1-(3-methylphenyl)ethanone hydrobromide

: 631-58-3
thiopropanamide

: 303162-39-2
4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine

Guidance literature:: In N,N-dimethyl-formamide;

Reference yield: 55.0%

: 303162-37-0
2-(2-tert-butoxycarbonylamino-pyridin-4-yl)-1-(3-methylphenyl)ethanone

2N-hydrochloric acid: 2N-hydrochloric acid

: 365428-42-8
5-[2-(tert-butoxycarbonylamino)-4-pyridyl]-2-ethyl-4-(3-methylphenyl)-1,3-thiazole

: 144-55-8
sodium hydrogencarbonate

: 303162-39-2
4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine

Guidance literature:

Reference yield:

: 303162-37-0
2-(2-tert-butoxycarbonylamino-pyridin-4-yl)-1-(3-methylphenyl)ethanone

: 303162-39-2
4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / Br₂; AcOH / 3 h / 80 °C

2: 60 percent / dimethylformamide / 14 h / 20 °C

With bromine; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm050165o