Unii-ywx923E9LD

Base Information

Chemical Name:Unii-ywx923E9LD
CAS No.:304647-55-0
Molecular Formula:C18H16F3N3O4S
Molecular Weight:427.404
Hs Code.:
UNII:YWX923E9LD
Nikkaji Number:J2.044.247F
Pharos Ligand ID:Z6RH6XJZ2272
ChEMBL ID:CHEMBL148100
Mol file:304647-55-0.mol

Synonyms:2-hydroxymethyl-4-(5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl)-1-benzenesulfonamide;DRF 4367;DRF-4367;DRF4367

Suppliers and Price of Unii-ywx923E9LD

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of Unii-ywx923E9LD

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:5
Exact Mass:427.08136166
Heavy Atom Count:29
Complexity:650

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CC(=NN2C3=CC(=C(C=C3)S(=O)(=O)N)CO)C(F)(F)F

Technology Process of Unii-ywx923E9LD

There total 4 articles about Unii-ywx923E9LD which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 15191-68-1
4,4,4-trifluoro-1-(4-methoxyphenyl)-1,3-butanedione

: 4-hydrazino-2-hydroxymethyl-1-benzenesulfonamide hydrochloride

: 2-hydroxymethyl-4-[3-(4-methoxy-phenyl)-5-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide

: 304647-55-0
DRF-4367

Guidance literature:: In ethanol; at 50 - 60 ℃;
DOI:10.1016/j.ejmech.2005.03.016

Reference yield:

: 4-hydrazino-2-hydroxymethyl-1-benzenesulfonamide hydrochloride

: 910303-55-8
(Z)-1,1,1-trifluoro-4-hydroxy-4-(4-methoxyphenyl)but-3-en-2-one

: 304647-55-0
DRF-4367

Guidance literature:: 4-hydrazino-2-hydroxymethyl-1-benzenesulfonamide hydrochloride; With hydrogenchloride; In methanol; isopropyl alcohol; at 20 ℃; for 0.5h; pH=1 - 2;

(Z)-1,1,1-Trifluoro-4-hydroxy-4-(4-methoxy-phenyl)-but-3-en-2-one; In ethanol; at 50 - 60 ℃;
DOI:10.1039/b402787f

Reference yield:

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 304647-55-0
DRF-4367

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / -5 - 0 °C

1.2: 90 percent / dimethylformamide / 20 °C

2.1: 79 percent / ethanol / 50 - 60 °C

With sodium hydride; In ethanol; N,N-dimethyl-formamide; 1.2: Claisen condensation;
DOI:10.1016/j.ejmech.2005.03.016