N-phenylquinolin-4-amine

Base Information

• Chemical Name: N-phenylquinolin-4-amine
• CAS No.: 30696-07-2
• Molecular Formula: C15H12N2
• Molecular Weight: 220.274
• Hs Code.: 2933499090
• ChEMBL ID: CHEMBL1644358
• DSSTox Substance ID: DTXSID50408552
• Nikkaji Number: J88.680G
• Wikidata: Q82214063
• Mol file: 30696-07-2.mol

Synonyms:N-phenylquinolin-4-amine;30696-07-2;4-Quinolinamine, N-phenyl-;CHEMBL1644358;4-anilinoquinoline;Phenyl-quinolin-4-yl-amine;SCHEMBL170830;DTXSID50408552;NRTUTGBOQZQBMB-UHFFFAOYSA-N;BDBM50246487;MFCD00958207;AKOS005141888;CCG-290214;SB70666;SS-4706;CS-0450822;F73741

Chemical Property of N-phenylquinolin-4-amine

Chemical Property:

• Melting Point: 230 °C
• Boiling Point: 380.2±17.0 °C(Predicted)
• PKA: 6.70±0.13(Predicted)
• PSA: 28.15000
• Density: 1.204±0.06 g/cm3(Predicted)
• LogP: 3.40030
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 220.100048391
• Heavy Atom Count: 17
• Complexity: 235

Purity/Quality:

99%, ^*data from raw suppliers

N-Phenylquinolin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC2=CC=NC3=CC=CC=C32

Technology Process of N-phenylquinolin-4-amine

There total 17 articles about N-phenylquinolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-chloroquinoline (611-35-8) + aniline (62-53-3) → phenyl-quinolin-4-yl-amine (30696-07-2)

Guidance literature:

at 150 ℃; for 0.25h; Microwave irradiation; Neat (no solvent);

DOI:10.1016/j.bmc.2010.11.059

Reference yield: 96.0%

4(1H)-quinolinone (529-37-3) + phenyl isocyanate (103-71-9) → phenyl-quinolin-4-yl-amine (30696-07-2)

Guidance literature:

at 210 ℃;

DOI:10.1021/jo0013397

Reference yield: 95.0%

4-anilino-3-quinolinesulfonic acid → phenyl-quinolin-4-yl-amine (30696-07-2)

Guidance literature:

With sulfuric acid; for 5h; Heating;

DOI:10.3987/COM-97-8003

upstream raw materials:

4-chloroquinoline

aniline

4-anilino-2-chloroquinoline

1,4-dithiino[2,3-c:5,6-c']diquinoline

Downstream raw materials:

N-phenyl-N-quinolin-4-yl-acetamide

N-phenyl-N-1,2,3,4-tetrahydroquinolin-4-ylacetamide

cis-N-Phenyl-N-[1-(thiophene-2-carbonyl)-1,2,3,4-tetrahydro-quinolin-4-yl]-acetamide