(S)-tert-Butyl (2,5-dioxotetrahydrofuran-3-yl)carbamate

Base Information

Chemical Name:(S)-tert-Butyl (2,5-dioxotetrahydrofuran-3-yl)carbamate
CAS No.:30750-74-4
Molecular Formula:C₉H₁₃NO₅
Molecular Weight:215.206
Hs Code.:2924199090
DSSTox Substance ID:DTXSID10545977
Nikkaji Number:J875.524H
Wikidata:Q72510044
Mol file:30750-74-4.mol

Synonyms:30750-74-4;(S)-tert-Butyl (2,5-dioxotetrahydrofuran-3-yl)carbamate;Boc-L-aspartic anhydride;tert-butyl N-[(3S)-2,5-dioxooxolan-3-yl]carbamate;Boc-L-asparticanhydride;N-boc-l-asparticanhydride;SCHEMBL8355012;DTXSID10545977;tert-butyl (S)-(2,5-dioxotetrahydrofuran-3-yl)carbamate;NPSWWCAEJQQFGG-YFKPBYRVSA-N;N-t-Butyloxycarbonyl-L-aspartic acid anhydride;(S)-3-(tert butoxycarbonylamino)succinic anhydride;(S)-3-(tert-butoxycarbonylamino)succinic anhydride;A919203;tert-Butyl [(3S)-2,5-dioxooxolan-3-yl]carbamate;(S)-tert-butyl 2,5-dioxotetrahydrofuran-3-ylcarbamate

Suppliers and Price of (S)-tert-Butyl (2,5-dioxotetrahydrofuran-3-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-tert-Butyl(2,5-dioxotetrahydrofuran-3-yl)carbamate 95+%
25g
$ 160.00

Crysdot
(S)-tert-Butyl(2,5-dioxotetrahydrofuran-3-yl)carbamate 95+%
10g
$ 80.00

Crysdot
(S)-tert-Butyl(2,5-dioxotetrahydrofuran-3-yl)carbamate 95+%
5g
$ 50.00

Crysdot
(S)-tert-Butyl(2,5-dioxotetrahydrofuran-3-yl)carbamate 95+%
100g
$ 480.00

Chemenu
tert-butyl(S)-(2,5-dioxotetrahydrofuran-3-yl)carbamate 95%
100g
$ 449.00

American Custom Chemicals Corporation
TERT-BUTYL N-[(3S)-2,5-DIOXOOXOLAN-3-YL]CARBAMATE 95.00%
5MG
$ 504.98

Alichem
(S)-tert-Butyl(2,5-dioxotetrahydrofuran-3-yl)carbamate
100g
$ 1070.00

Total 18 raw suppliers

Chemical Property of (S)-tert-Butyl (2,5-dioxotetrahydrofuran-3-yl)carbamate

Chemical Property:

Melting Point:134-135℃ (acetone ligroine )
Boiling Point:387.3±31.0 °C(Predicted)
PKA:10.14±0.20(Predicted)
PSA：85.19000
Density:1.25±0.1 g/cm3 (20 oC 760 Torr)
LogP:0.55760
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:0.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:215.07937252
Heavy Atom Count:15
Complexity:304

Purity/Quality:

97% ^*data from raw suppliers

(S)-tert-Butyl(2,5-dioxotetrahydrofuran-3-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CC(=O)OC1=O
Isomeric SMILES:CC(C)(C)OC(=O)N[C@H]1CC(=O)OC1=O

Technology Process of (S)-tert-Butyl (2,5-dioxotetrahydrofuran-3-yl)carbamate

There total 7 articles about (S)-tert-Butyl (2,5-dioxotetrahydrofuran-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 13726-67-5
Boc-Asp-OH

: 91240-51-6,120409-48-5,30750-74-4
N-tert-butyloxycarbonylaspartic acid anhydride

Guidance literature:: With diisopropyl-carbodiimide; In ethyl acetate; for 2h;
DOI:10.1055/s-2003-38733

Reference yield: 83.0%

: 56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3
L-Aspartic acid

: 24424-99-5
di-tert-butyl dicarbonate

: 91240-51-6,120409-48-5,30750-74-4
N-tert-butyloxycarbonylaspartic acid anhydride

Guidance literature:: L-Aspartic acid; di-tert-butyl dicarbonate; With sodium hydroxide; In methanol; at 30 - 35 ℃; for 3h; pH=9.3-9.5;

With acetic anhydride; at 25 - 35 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 91240-51-6,120409-48-5,30750-74-4
N-tert-butyloxycarbonylaspartic acid anhydride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / H₂O / 24 h / 20 °C

2: 2-(dimethylamino)isopropyl chloride hydrochloride / tetrahydrofuran / 4 h / 20 °C

With (2-chloropropyl)dimethylamine hydrochloride; sodium carbonate; In tetrahydrofuran; water;
DOI:10.1016/j.tet.2007.03.163