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Aspartic Acid

Base Information Edit
  • Chemical Name:Aspartic Acid
  • CAS No.:56-84-8
  • Deprecated CAS:181119-33-5,6899-03-2,2139279-07-3,181119-34-6,221628-95-1,26834-87-7,155436-59-2,155436-61-6,155436-63-8,155436-65-0,90819-17-3,1236300-18-7,1393950-57-6,1436923-03-3,2197132-19-5
  • Molecular Formula:C4H7NO4
  • Molecular Weight:133.104
  • Hs Code.:2922.49
  • European Community (EC) Number:200-291-6,614-886-7,642-993-9
  • ICSC Number:1439
  • UNII:30KYC7MIAI
  • DSSTox Substance ID:DTXSID7022621
  • Nikkaji Number:J9.169C
  • Wikipedia:Aspartic acid
  • Wikidata:Q178450
  • NCI Thesaurus Code:C29608
  • RXCUI:1169
  • Metabolomics Workbench ID:37126
  • ChEMBL ID:CHEMBL274323
  • Mol file:56-84-8.mol
Aspartic Acid

Synonyms:(+-)-Aspartic Acid;(R,S)-Aspartic Acid;Ammonium Aspartate;Aspartate;Aspartate Magnesium Hydrochloride;Aspartate, Ammonium;Aspartate, Calcium;Aspartate, Dipotassium;Aspartate, Disodium;Aspartate, Magnesium;Aspartate, Monopotassium;Aspartate, Monosodium;Aspartate, Potassium;Aspartate, Sodium;Aspartic Acid;Aspartic Acid, Ammonium Salt;Aspartic Acid, Calcium Salt;Aspartic Acid, Dipotassium Salt;Aspartic Acid, Disodium Salt;Aspartic Acid, Hydrobromide;Aspartic Acid, Hydrochloride;Aspartic Acid, Magnesium (1:1) Salt, Hydrochloride, Trihydrate;Aspartic Acid, Magnesium (2:1) Salt;Aspartic Acid, Magnesium-Potassium (2:1:2) Salt;Aspartic Acid, Monopotassium Salt;Aspartic Acid, Monosodium Salt;Aspartic Acid, Potassium Salt;Aspartic Acid, Sodium Salt;Calcium Aspartate;Dipotassium Aspartate;Disodium Aspartate;L Aspartate;L Aspartic Acid;L-Aspartate;L-Aspartic Acid;Magnesiocard;Magnesium Aspartate;Mg-5-Longoral;Monopotassium Aspartate;Monosodium Aspartate;Potassium Aspartate;Sodium Aspartate

Suppliers and Price of Aspartic Acid
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • L-Aspartic Acid
  • 100g
  • $ 77.00
  • TRC
  • L-Aspartic acid
  • 25 g
  • $ 75.00
  • TRC
  • L-Aspartic acid
  • 10g
  • $ 55.00
  • TCI Chemical
  • L-Aspartic Acid >99.0%(T)
  • 25g
  • $ 16.00
  • TCI Chemical
  • L-Aspartic Acid >99.0%(T)
  • 500g
  • $ 48.00
  • Sigma-Aldrich
  • L-Aspartic acid certified reference material, TraceCERT
  • 100mg
  • $ 104.00
  • Sigma-Aldrich
  • Aspartic acid European Pharmacopoeia (EP) Reference Standard
  • a1330000
  • $ 190.00
  • Sigma-Aldrich
  • L-Aspartic acid PharmaGrade, Ajinomoto, EP, JP, USP, manufactured under appropriate GMP controls for Pharma or Biopharmaceutical production, suitable for cell culture
  • 100g
  • $ 159.00
  • Sigma-Aldrich
  • L-Aspartic acid reagent grade, ≥98% (HPLC)
  • 1kg
  • $ 200.00
  • Sigma-Aldrich
  • L-Aspartic acid from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%
  • 1kg
  • $ 258.00
Total 362 raw suppliers
Chemical Property of Aspartic Acid Edit
Chemical Property:
  • Appearance/Colour:White crystalline powder 
  • Melting Point:>300 °C (dec.)(lit.) 
  • Refractive Index:1.4540 (estimate) 
  • Boiling Point:264.121 °C at 760 mmHg 
  • PKA:1.99(at 25℃) 
  • Flash Point:113.536 °C 
  • PSA:100.62000 
  • Density:1.515 g/cm3 
  • LogP:-0.42670 
  • Storage Temp.:Store at RT. 
  • Solubility.:H2O: 5 mg/mL 
  • Water Solubility.:5 g/L (25 ºC) 
  • XLogP3:-2.8
  • Hydrogen Bond Donor Count:3
  • Hydrogen Bond Acceptor Count:5
  • Rotatable Bond Count:3
  • Exact Mass:133.03750770
  • Heavy Atom Count:9
  • Complexity:133
Purity/Quality:

99% *data from raw suppliers

L-Aspartic Acid *data from reagent suppliers

Safty Information:
  • Pictogram(s): HarmfulXn, IrritantXi 
  • Hazard Codes:Xi,Xn 
  • Statements: 36-36/37/38-20/21/22 
  • Safety Statements: 26-24/25-22-36 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Chemical Classes:Biological Agents -> Amino Acids and Derivatives
  • Canonical SMILES:C(C(C(=O)O)N)C(=O)O
  • Isomeric SMILES:C([C@@H](C(=O)O)N)C(=O)O
  • Recent ClinicalTrials:Prevention and Treatment for COVID -19 (Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2) Associated Severe Pneumonia in the Gambia
  • Recent EU Clinical Trials:International phase 3 trial in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) testing imatinib in combination with two different cytotoxic chemotherapy backbones
  • Inhalation Risk:Evaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
  • Effects of Short Term Exposure:The substance is irritating to the eyes and respiratory tract.
  • Nature and Forms Aspartic acid exists in two enantiomeric forms: L-aspartic acid and D-aspartic acid.
    L-aspartic acid is the more common form and is used in protein synthesis and neurotransmission.
    D-aspartic acid is less common and is associated with neurogenesis and the endocrine system.
  • Constituent of Proteins Aspartic acid is one of the top three main constituents of proteins.
  • Bio functionality and Uses Aspartic acid is an acidic amino acid that can chelate or adsorb metal ions.
    It finds wide application in food, beverage, pharmaceutical, cosmetic, and agricultural industries.
    L-aspartic acid is used as a nutritional supplement and in combination with phenylalanine to produce aspartame, an artificial sweetener.
    It aids in immune function, combats depression, and supports energy production, fatigue resistance, RNA and DNA synthesis, and liver detoxification.
    It serves as an intermediary substrate in pharmaceutical and organic chemical manufacturing.
    Derivatives of aspartic acids, such as acetyl aspartic acid and polyaspartic acid, have various industrial uses including in cosmetics, fertilizers, and hydrogels.
  • Market and Production The global aspartic acid market consists of several small company players and is growing, particularly in the medical sector.
    There are three main methods of production: protein extraction, chemical synthesis, and enzymatic conversion. Enzymatic conversion is the favored route due to its efficiency.
  • Industrial Relevance and Growth Aspartic acid has significant potential for industrial relevance and is expected to see increased demand, particularly in the medical and beverage sectors in regions like Asia Pacific.
  • General Description L-Aspartic acid (also known as L-Aspartate) is a non-essential amino acid that serves as a key intermediate in metabolic pathways, including the Krebs cycle, where it contributes to energy production by forming oxalacetate. It is also utilized as a chiral building block in organic synthesis for producing bioactive compounds such as pyridine derivatives, pyrrolidinones, and β-lactam antibiotics. Additionally, its N-acyl derivatives exhibit CNS stimulant effects by interacting with excitatory amino acid receptors, while its salts (e.g., K and Mg aspartate) enhance cellular metabolism by stimulating oxygen consumption and CO? production. Its versatility extends to protease-catalyzed glycopeptide synthesis, where it aids in forming biologically active conjugates.
Technology Process of Aspartic Acid

There total 279 articles about Aspartic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogenchloride; potassium tert-butylate; bromine; triethylamine; nickel dichloride; Yield given. Multistep reaction; 1.) iPrOH, 5 deg C, 2.) CH3CN, -50 deg C, 3.) 25 deg C, H2O, reflux, 1 h;
DOI:10.1039/c39880001336
Guidance literature:
With L-alanin; In water; for 24h; Product distribution; Ambient temperature; other optically active amino acids;
DOI:10.1246/bcsj.56.653
Guidance literature:
With hydrogenchloride; trifluoroacetic acid; for 15h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;
DOI:10.1021/jo00129a038
Refernces Edit

Useful synthesis of 2,3,6-tri- and 2,3,5,6-tetrasubstitutedpyridine derivatives from aspartic acid

10.3987/COM-04-10206

The research focuses on the development of a new synthetic method for producing 2,3,6-tri- and 2,3,5,6-tetrasubstituted pyridine derivatives, which are key structural components of thiostrepton-type macrocyclic antibiotics. The synthesis is achieved starting from L-α-aspartic acid through the use of an α-dehydroamino acid derivative. The study involves a series of chemical reactions, including esterification, reduction, oxidation, and cyclization, utilizing reagents such as DCC, HOBt, NaBH4, SO3.pyridine, Jones reagent, MnO2, MeI, Ag2CO3, and Pd-C/H2. The analyses used to characterize the synthesized compounds include melting point measurements, infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and elemental analysis, which confirm the structure and purity of the products.

A versatile approach to protected (S)-aspartimide, (4S)-amino-2- pyrrolidinone and (3S)-aminopyrrolidine from (S)-aspartic acid

10.1080/00397910008086885

The research details a versatile approach to synthesizing protected (S)-aspartimide, (4S)-amino-2-pyrrolidinone, and (3S)-aminopyrrolidine derivatives starting from (S)-aspartic acid. The purpose of this study was to develop a unified method for these structurally related compounds, which are significant due to their presence in various bioactive compounds and their potential use as chiral ligands in asymmetric synthesis. The researchers successfully synthesized (S)-1-benzyl-3-p-toluenesulfonylamino-2,5-pyrrolidinedione, (S)-1-benzyl-3-p-toluenesulfonylaminopyrrolidine, and (S)-1-benzyl-4-p-toluenesulfonylamino-2-pyrrolidinone using a series of reactions involving tosylation, cyclization, and selective reductions. Key chemicals used in the process included (S)-aspartic acid, acetic anhydride, benzylamine, lithium aluminium hydride, sodium borohydride, and various solvents such as ethyl acetate and tetrahydrofuran (THF). The study concluded with the establishment of a useful approach to these compounds, which are valuable building blocks for several bioactive compounds, and noted that further investigation into the use of the synthesized compounds as chiral ligands for asymmetric synthesis is underway.

CNS STIMULANT EFFECT OF N-ACYLDERVATIVES OF GLUTAMIC AND ASPARTIC ACIDS

10.1007/BF00766247

The research investigates the central nervous system (CNS) stimulant effects of N-acyl derivatives of glutamic and aspartic acids. The study explores how these derivatives interact with glutamate-recognizing sites in rat brain synaptic membranes and their convulsive activity when directly injected into the brain. Key chemicals used in the research include N-acyl derivatives of glutamic and aspartic acids (I-XVII), which were synthesized from various starting materials such as phenoxyacetic acid, benzoylpropionic acid, phenylbutyric acid, naphthylacetic acid, and diphenyl-ethoxyacetic acid. Other notable chemicals include glutamic diethyl ether, NMDA (N-methyl-D-aspartic acid), and kainate, which were used to test the convulsive and anticonvulsive activities of the synthesized compounds. The study aims to understand the relationship between the structure of these derivatives and their pharmacological activity, revealing that the presence and arrangement of polar and lipophilic groups in the acyl radical significantly influence their stimulant effects and potential as new pharmacologically active compounds targeting the excitatory amino acid system in the CNS.

Effect of K and Mg Aspartate on Cellular Metabolism

10.1007/BF02142154

The study investigates the effects of K and Mg aspartate on cellular metabolism, specifically focusing on oxygen consumption and respiratory CO? production in isolated rat nephrons. The chemicals involved include aspartate, which is proposed to stimulate cellular metabolic processes by potentially acting as an anaerobic generator of CO? or stimulating the tricarboxylic acid cycle after deamination. The study found that the addition of aspartate significantly increased oxygen consumption and CO? production without altering the respiratory quotient, suggesting that aspartate enhances cellular metabolism through its role in producing oxalacetate, a key component of the Krebs cycle. This effect is more complex than simply acting as a cation carrier for K and Mg, and may also involve a vascular action due to the vasodilating effect of oxalacetate on small vessels.

Ready protease-catalyzed synthesis of carbohydrate-amino acid conjugates.

10.1039/b104137c

The research focuses on the protease-catalyzed synthesis of carbohydrate-amino acid conjugates, specifically glycopeptide analogues, through a highly regioselective and carbohydrate-specific process. The purpose of this study was to develop a ready and short route for the creation of ester-linked glycopeptides, which are known to display a wide variety of potent biological activities with potential therapeutic and commercial value. The researchers used amino acid vinyl ester acyl donors and minimally or completely unprotected carbohydrate acyl acceptors to probe the active sites of proteases. They found that the yield efficiencies were modulated by the carbohydrate C-2 substituent, which could be exploited for selective one-pot syntheses. The study successfully established a method for constructing glycan-peptide conjugates with yields ranging from 23–76%, which is comparable to or better than alternative routes employing protection-deprotection strategies. The chemicals used in the process included serine protease subtilisin Bacillus lentus (SBL) as a catalyst, and amino acids such as phenylalanine, aspartic acid, and glutamic acid, along with various carbohydrate acyl acceptors. The research concluded that the protease-catalyzed transesterification process is a powerful method for creating glycopeptides, which can be further extended at their sugar reducing end or peptide N-terminal, and that the substrate specificity of the proteases SBL and TLCLEC showed a strong preference for phenylalanine with flexibility in N-protection.

Enantioselective synthesis of 2-isocephem and 2-isooxacephem antibiotics

10.1039/a700650k

The research focuses on the enantioselective synthesis of 2-isocephem and 2-isooxacephem antibiotics, which are nuclear analogues of β-lactam antibiotics and have shown potent antibacterial activity. The purpose of the study was to develop a method for synthesizing enantiomerically pure forms of these compounds, addressing the challenge of constructing cis-oriented chiral centers at the azetidinone ring. The researchers used L-aspartic acid as a chiral starting material and successfully synthesized the target compounds through a series of chemical reactions involving azide introduction, four-component condensation, and intramolecular acylation. Key chemicals used in the process included azido lactone, p-nitrobenzyl isocyanide, formaldehyde, 2,2-diethoxyacetaldehyde, and various protecting and deprotecting agents.

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