Urea, N-[4-[5-(chloromethyl)-1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro- 2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy-

Base Information

• Chemical Name: Urea, N-[4-[5-(chloromethyl)-1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro- 2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy-
• CAS No.: 308831-89-2
• Molecular Formula: C28H21ClF2N4O4S
• Molecular Weight: 583.015
• Mol file: 308831-89-2.mol

Synonyms:

Chemical Property of Urea, N-[4-[5-(chloromethyl)-1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro- 2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy-

Chemical Property:

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Useful:

Technology Process of Urea, N-[4-[5-(chloromethyl)-1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro- 2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy-

There total 2 articles about Urea, N-[4-[5-(chloromethyl)-1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro- 2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(4-(5-((benzyl(methyl)amino)methyl)-1-(2,6-difluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea (308831-61-0) → 5-chloromethyl-1-(2,6-difluorobenzyl)-6-[4-(3-methoxyureido)phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (308831-89-2)

Guidance literature:

With carbonochloridic acid 1-chloro-ethyl ester; In tetrahydrofuran; at -78 - 25 ℃; for 2h;

Reference yield: 96.0%

carbonochloridic acid 1-chloro-ethyl ester (50893-53-3) + N-(4-(5-((benzyl(methyl)amino)methyl)-1-(2,6-difluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea (308831-61-0) → 5-chloromethyl-1-(2,6-difluorobenzyl)-6-[4-(3-methoxyureido)phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (308831-89-2)

Guidance literature:

In tetrahydrofuran;

Reference yield: 89.0%

5-chloromethyl-1-(2,6-difluorobenzyl)-6-[4-(3-methoxyureido)phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione (308831-89-2) + N-methyl-N-(2-methoxyethyl)amine (38256-93-8) → 1-{4-[1-(2,6-difluorobenzyl)-5-{[(2-methoxyethyl)(methyl)amino]methyl}-2,4-dioxo-3-phenyl-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea

Guidance literature:

With potassium iodide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

upstream raw materials:

N-(4-(5-((benzyl(methyl)amino)methyl)-1-(2,6-difluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl)phenyl)-N'-methoxyurea

carbonochloridic acid 1-chloro-ethyl ester

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