3-(4-Nitrophenyl)-5-phenylisoxazole

Base Information

• Chemical Name: 3-(4-Nitrophenyl)-5-phenylisoxazole
• CAS No.: 31108-56-2
• Molecular Formula: C15H10N2O3
• Molecular Weight: 266.256
• Hs Code.: 2934999090
• Mol file: 31108-56-2.mol

Synonyms:3-p-nitrophenyl-5-phenylisoxazole;

Chemical Property of 3-(4-Nitrophenyl)-5-phenylisoxazole

Chemical Property:

• PSA: 71.85000
• LogP: 4.44000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Nitrophenyl)-5-phenylisoxazole

There total 24 articles about 3-(4-Nitrophenyl)-5-phenylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-(p-nitrophenyl)-5-phenyl-2-isoxazoline (50438-66-9) → 3-(4-nitrophenyl)-5-phenylisoxazole (31108-56-2)

Guidance literature:

With nitrosylsulfuric acid; In nitromethane; at 20 ℃;

DOI:10.1007/s11172-018-2103-x

Reference yield: 95.0%

phenylacetylene (536-74-3) + 4-nitrobenzohydroximoyl chloride (1011-84-3) → 3-(4-nitrophenyl)-5-phenylisoxazole (31108-56-2)

Guidance literature:

With copper(I) oxide; triethylamine; In ethanol; at 60 ℃; Inert atmosphere;

Reference yield: 85.0%

C15H12N2O3 → 3-(4-nitrophenyl)-5-phenylisoxazole (31108-56-2)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; oxygen; copper diacetate; In dimethyl sulfoxide; at 100 ℃; for 12h; under 760.051 Torr;

DOI:10.1039/c7ra11436b

upstream raw materials:

1-(4-nitro-phenyl)-3-phenyl-propane-1,3-dione

3,5-diphehylisoxazole

N-methyl-N-(1-phenylethenyl)aniline

4-nitrobenzohydroximoyl chloride

Downstream raw materials:

2-Methyl-3-(4-nitro-phenyl)-5-phenyl-isoxazol-2-ium; iodide