BenzeneethanaMine, 2-Methoxy-, (Hydrochloride)

Base Information

• Chemical Name: BenzeneethanaMine, 2-Methoxy-, (Hydrochloride)
• CAS No.: 3167-07-5
• Molecular Formula: C9H13NO
• Molecular Weight: 151.2056
• Hs Code.: 2922299090
• Mol file: 3167-07-5.mol

Synonyms:2-Methoxyphenethylamine hydrochloride;2-Methoxyphenethylamine HCl;

Chemical Property of BenzeneethanaMine, 2-Methoxy-, (Hydrochloride)

Chemical Property:

• Boiling Point: 235 °C at 760 mmHg
• Flash Point: 95 °C
• PSA: 35.25000
• Density: 1.008 g/cm³
• LogP: 2.69870

Purity/Quality:

99% ^*data from raw suppliers

2-MethoxyphenylethylamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BenzeneethanaMine, 2-Methoxy-, (Hydrochloride)

There total 3 articles about BenzeneethanaMine, 2-Methoxy-, (Hydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-methoxy-benzeneacetonitrile (7035-03-2) → o-Methoxyphenylethylamine hydrochloride (3167-07-5)

Guidance literature:

2-methoxy-benzeneacetonitrile; With borane-ammonia complex; C₁₇H₁₆BrMnN₂O₃S; In hexane; at 60 ℃; for 12h;

With hydrogenchloride; In diethyl ether; water;

DOI:10.1021/acscatal.0c05406

Reference yield:

(E)-1-tert-butyl-N-(2-methoxystyryl)-1,1-dimethylsilanamine → o-Methoxyphenylethylamine hydrochloride (3167-07-5)

Guidance literature:

(E)-1-tert-butyl-N-(2-methoxystyryl)-1,1-dimethylsilanamine; With 2.5% wt Pd/C; hydrogen; In benzene-d6; at 20 ℃; for 40h; under 760.051 Torr;

With hydrogenchloride; In diethyl ether; benzene-d6; ethyl acetate;

DOI:10.1021/jacs.7b13783

Reference yield:

3-<(E)-<2-(2-methoxyphenyl)ethenyl>>-4,5-diphenyl-2(3H)oxazolone (148715-52-0) → o-Methoxyphenylethylamine hydrochloride (3167-07-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; Yield given. Multistep reaction; 1) EtOH, H₂O, HOAc, 50 deg C, 50 psi, 4h, 2) EtOH;

DOI:10.1021/jo00064a015

upstream raw materials:

3-<(E)-<2-(2-methoxyphenyl)ethenyl>>-4,5-diphenyl-2(3H)oxazolone

2-methoxy-benzeneacetonitrile

Refernces

• 1、 Lui, Erica K. J.,Brandt, Jason W.,Schafer, Laurel L.. "Regio- and stereoselective hydroamination of alkynes using an ammonia surrogate: Synthesis of N -Silylenamines as reactive synthons". supporting information. p. 4973 - 4976. Retrieved 2018/04/24.