Benzenecarboximidoyl chloride, N-cyclohexyl-

Base Information

• Chemical Name: Benzenecarboximidoyl chloride, N-cyclohexyl-
• CAS No.: 31144-23-7
• Molecular Formula: C13H16ClN
• Molecular Weight: 221.73
• Mol file: 31144-23-7.mol

Synonyms:

Chemical Property of Benzenecarboximidoyl chloride, N-cyclohexyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenecarboximidoyl chloride, N-cyclohexyl-

There total 6 articles about Benzenecarboximidoyl chloride, N-cyclohexyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-benzoylcyclohexylamine (1759-68-8) → N-cyclohexylbenzimidoyl chloride (31144-23-7)

Guidance literature:

With thionyl chloride; at 70 ℃; for 2.5h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1002/anie.201405027

Reference yield:

N-benzoylcyclohexylamine (1759-68-8) → N-Cyclohexyl-benzimidoylchlorid (31144-23-7)

Guidance literature:

With 2,6-dimethylpyridine; oxalyl dichloride; carbon dioxide; carbon monoxide; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo200101q

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexylbenzimidoyl chloride (31144-23-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: thionyl chloride / 20 °C

With thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1039/c3cc41690a

upstream raw materials:

N-benzoylcyclohexylamine

benzoic acid

cyclohexylamine

benzoyl chloride

Downstream raw materials:

N-Cyclohexyl-N'-{4-[2-(methyl-phenyl-amino)-ethoxy]-phenyl}-benzamidine

N-Cyclohexyl-N'-[4-(2-diisopropylamino-ethoxy)-phenyl]-benzamidine

N-Cyclohexyl-benzimidoylfluorid

Cyclohexyl-[1-(3,5-dimethyl-pyrazol-1-yl)-1-phenyl-meth-(E)-ylidene]-amine

Refernces

• 1、 Lin, Jian-Ping,Long, Ya-Qiu. "Transition metal-free one-pot synthesis of 2-substituted 3-carboxy-4-quinolone and chromone derivatives". supporting information. p. 5313 - 5315. Retrieved 2013/06/27.
• 2、 Kuszpit, Michael R.,Wulff, William D.,Tepe, Jetze J.. "One-pot synthesis of 2-imidazolines via the ring expansion of imidoyl chlorides with aziridines". experimental part. p. 2913 - 2919. Retrieved 2011/06/19.