1(2H)-Quinolinecarboxylic acid, 3,4-dihydro-6-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]-2-methyl-, phenylmethyl ester, (2R)-

Base Information

Chemical Name:1(2H)-Quinolinecarboxylic acid, 3,4-dihydro-6-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]-2-methyl-, phenylmethyl ester, (2R)-
CAS No.:312306-08-4
Molecular Formula:C22H24N2O5
Molecular Weight:396.443
Hs Code.:
Mol file:312306-08-4.mol

Synonyms:

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Chemical Property of 1(2H)-Quinolinecarboxylic acid, 3,4-dihydro-6-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]-2-methyl-, phenylmethyl ester, (2R)-

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Technology Process of 1(2H)-Quinolinecarboxylic acid, 3,4-dihydro-6-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]-2-methyl-, phenylmethyl ester, (2R)-

There total 6 articles about 1(2H)-Quinolinecarboxylic acid, 3,4-dihydro-6-[(5R)-5-(hydroxymethyl)-2-oxo-3-oxazolidinyl]-2-methyl-, phenylmethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 312306-08-4
benzyl (2R)-6-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate

: 312306-09-5
Benzyl (2R)-6-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate

Guidance literature:

Reference yield:

: 65079-19-8
2-methylquinolin-6-amine

: 312306-08-4
benzyl (2R)-6-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂; H₂SO₄ / PtO₂ / methanol

2: NaHCO₃ / acetone

3: n-BuLi / tetrahydrofuran

With n-butyllithium; sulfuric acid; hydrogen; sodium hydrogencarbonate; platinum(IV) oxide; In tetrahydrofuran; methanol; acetone;
DOI:10.1016/j.bmcl.2003.07.029

Reference yield:

: 613-30-9
2-methyl-6-nitroquinoline

: 312306-08-4
benzyl (2R)-6-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: SnCl₂*H₂O / ethanol / Heating

2: H₂; H₂SO₄ / PtO₂ / methanol

3: NaHCO₃ / acetone

4: n-BuLi / tetrahydrofuran

With n-butyllithium; sulfuric acid; hydrogen; sodium hydrogencarbonate; tin(ll) chloride; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; acetone;
DOI:10.1016/j.bmcl.2003.07.029