Benzaldehyde, 4-[[[tris(1-methylethyl)silyl]oxy]methyl]-

Base Information

• Chemical Name: Benzaldehyde, 4-[[[tris(1-methylethyl)silyl]oxy]methyl]-
• CAS No.: 313279-15-1
• Molecular Formula: C17H28O2Si
• Molecular Weight: 292.494
• DSSTox Substance ID: DTXSID70445505
• Mol file: 313279-15-1.mol

Synonyms:313279-15-1;4-(((Triisopropylsilyl)oxy)methyl)benzaldehyde;Benzaldehyde, 4-[[[tris(1-methylethyl)silyl]oxy]methyl]-;SCHEMBL2857839;DTXSID70445505;FT-0718489

Chemical Property of Benzaldehyde, 4-[[[tris(1-methylethyl)silyl]oxy]methyl]-

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 292.185856666
• Heavy Atom Count: 20
• Complexity: 270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)[Si](C(C)C)(C(C)C)OCC1=CC=C(C=C1)C=O

Technology Process of Benzaldehyde, 4-[[[tris(1-methylethyl)silyl]oxy]methyl]-

There total 5 articles about Benzaldehyde, 4-[[[tris(1-methylethyl)silyl]oxy]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

triisopropylsilyl chloride (13154-24-0) + 4-(hydroxylmethyl)benzaldehyde (52010-97-6) → 4-((triisopropylsilyloxy)methyl)benzaldehyde (313279-15-1)

Guidance literature:

With 1H-imidazole; triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 78.0%

(4-{[(triisopropylsilyl)oxy]methyl}phenyl)methanol (139706-47-1) → 4-((triisopropylsilyloxy)methyl)benzaldehyde (313279-15-1)

Guidance literature:

With manganese(IV) oxide; In tetrahydrofuran;

DOI:10.1021/jm000950v

Reference yield:

triisopropylsilyl chloride (13154-24-0) → 4-((triisopropylsilyloxy)methyl)benzaldehyde (313279-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran / 1 h

1.2: 64 percent / tetrahydrofuran

2.1: 78 percent / MnO₂ / tetrahydrofuran

With manganese(IV) oxide; sodium hydride; In tetrahydrofuran;

DOI:10.1021/jm000950v

upstream raw materials:

(4-{[(triisopropylsilyl)oxy]methyl}phenyl)methanol

triisopropylsilyl chloride

p-xylylene glycol

terephthalaldehyde,

Downstream raw materials:

4-(((2S,3S,E)-3-(methoxymethyl)-5,12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-4-yl)methyl)benzaldehyde