4-HYDROXYMETHYLBENZALDEHYDE

Base Information

• Chemical Name: 4-HYDROXYMETHYLBENZALDEHYDE
• CAS No.: 52010-97-6
• Molecular Formula: C8H8O2
• Molecular Weight: 136.15
• Hs Code.: 2912491000
• Mol file: 52010-97-6.mol

Synonyms:p-Tolualdehyde,a-hydroxy- (6CI,7CI);Benzaldehyde,4-(hydroxymethyl)-;

Chemical Property of 4-HYDROXYMETHYLBENZALDEHYDE

Chemical Property:

• Melting Point: 47 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 291.219 °C at 760 mmHg
• PKA: 14.00±0.10(Predicted)
• Flash Point: 122.49 °C
• PSA: 37.30000
• Density: 1.185 g/cm³
• LogP: 0.99140
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

4-(Hydroxymethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXYMETHYLBENZALDEHYDE

There total 38 articles about 4-HYDROXYMETHYLBENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-(hydroxymethyl)benzaldehyde diethyl acetal (125734-44-3) → 4-(hydroxylmethyl)benzaldehyde (52010-97-6)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; for 1h;

Reference yield: 100.0%

4-(hydroxymethyl)benzaldehyde dimethyl acetal (183057-64-9) → 4-(hydroxylmethyl)benzaldehyde (52010-97-6)

Guidance literature:

With sulfuric acid; water; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield: 95.0%

4-Carboxybenzaldehyde (619-66-9) → 4-(hydroxylmethyl)benzaldehyde (52010-97-6)

Guidance literature:

With samarium diiodide; water; samarium(III) trifluoromethanesulfonate; In tetrahydrofuran; methanol; at 20 ℃; for 0.1h;

DOI:10.1016/S0040-4039(99)02051-1

upstream raw materials:

4-chloromethylbenzaldehyde

p-Xylylene dichloride

p-xylylene glycol

terephthalaldehyde,

Downstream raw materials:

4-((tert-butyldimethylsilyloxy)methyl)benzaldehyde

4-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]benzaldehyde

4-(4-Benzoyl-2-benzyl-3-hydroxy-phenoxymethyl)-benzaldehyde

4-(4-Formyl-benzyloxy)-2-hydroxy-3-propyl-benzoic acid methyl ester

Refernces

• 1、 Zhang, Haiyuan,Xie, Fang,Cheng, Muhua,Peng, Fangyu. "Novel Meta-iodobenzylguanidine-Based Copper Thiosemicarbazide-1-guanidinomethylbenzyl Anticancer Compounds Targeting Norepinephrine Transporter in Neuroblastoma". . p. 6985 - 6991. Retrieved 2019.
• 2、 Hu, Xiwei,Fan, Mengying,Zhu, Yangyang,Zhu, Qian,Song, Qiang,Dong, Zhengping. "Biomass-derived phosphorus-doped carbon materials as efficient metal-free catalysts for selective aerobic oxidation of alcohols". . p. 5274 - 5283. Retrieved 2019.
• 3、 Laxman, Kandala,Ravikanth, Mangalampalli. "Synthesis of Oxasmaragdyrin–Amino Acid Conjugates". . p. 5884 - 5891. Retrieved 2017.
• 4、 Bazan, Bart?omiej,Pa?asz, Aleksandra,Skalniak, ?ukasz,Cie?, Dariusz,Buda, Szymon,J?drzejowska, Katarzyna,G?omb, Sonia,Kamzol, Daniel,Czarnota, Kinga,Latos, Krystian,Kozie?, Krzysztof,Musielak, Bogdan. "Application of bioorthogonal hetero-Diels-Alder cycloaddition of 5-arylidene derivatives of 1,3-dimethylbarbituric acid and vinyl thioether for imaging inside living cells". supporting information. p. 6045 - 6058. Retrieved 2021/07/25.
• 5、 -. "Histone deacetylase inhibitor as well as preparation and application thereof". Paragraph 0042-0043. . Retrieved 2021/04/28.