2,2-DIMETHYL-1-PYRIDIN-2-YL-PROPAN-1-ONE

Base Information

• Chemical Name: 2,2-DIMETHYL-1-PYRIDIN-2-YL-PROPAN-1-ONE
• CAS No.: 31595-32-1
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• Hs Code.: 2933399090
• Mol file: 31595-32-1.mol

Synonyms:T-BUTYL 2-PYRIDYL KETONE;tert-butyl pyridin-2-yl ketone;2-(2,2-dimethyl-propionyl)pyridine;2,2-dimethyl-1-[2]pyridyl-propan-1-one;tert-butyl 2-pyridyl ketone;2-Pyridyl-t-butylketone;2,2-dimethyl-1-(pyridin-2-yl)propan-1-one;2,2-dimethyl-1-(2-pyridyl)-propanone;2-pivaloylpyridine;

Chemical Property of 2,2-DIMETHYL-1-PYRIDIN-2-YL-PROPAN-1-ONE

Chemical Property:

• Vapor Pressure: 0.0505mmHg at 25°C
• Boiling Point: 235.3oC at 760 mmHg
• PKA: 3.06±0.10(Predicted)
• Flash Point: 101.9oC
• PSA: 29.96000
• Density: 0.996g/cm3
• LogP: 2.31040

Purity/Quality:

98% ^*data from raw suppliers

T-Butyl2-pyridylketone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-DIMETHYL-1-PYRIDIN-2-YL-PROPAN-1-ONE

There total 12 articles about 2,2-DIMETHYL-1-PYRIDIN-2-YL-PROPAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-bromo-pyridine (109-04-6) + pivalaldehyde (630-19-3) → 2,2-dimethyl-1-pyridin-2-yl-propan-1-one (31595-32-1)

Guidance literature:

2-bromo-pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

pivalaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With iodine; potassium carbonate; In tert-butyl alcohol; for 5h; Reflux;

DOI:10.1016/j.tet.2011.12.023

Reference yield: 70.0%

2-bromo-pyridine (109-04-6) + tert-butyl isocyanide (630-18-2) → 2,2-dimethyl-1-pyridin-2-yl-propan-1-one (31595-32-1)

Guidance literature:

2-bromo-pyridine; With n-butyllithium; In diethyl ether; at -78 ℃; for 1.5h; Inert atmosphere;

tert-butyl isocyanide; In diethyl ether; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.200801929

Reference yield: 51.0%

1-<(2,2-Dimethylpropionyloxy)(4-methylphenyl)methyl>pyridinium-chlorid → 2,2-dimethyl-1-pyridin-2-yl-propan-1-one (31595-32-1)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at -80 ℃; for 2h;

upstream raw materials:

2-Cyanopyridine

tert-butylmagnesium bromide

2-pyridyllithium

tert-butyl isocyanide

Downstream raw materials:

1,4-diphenyl-1,3-butadiene

4-Methyl-benzenesulfinic acid [2,2-dimethyl-1-pyridin-2-yl-prop-(E)-ylidene]-amide