ethyl (5-fluoro-1H-indol-3-yl)acetate

Base Information

Chemical Name:ethyl (5-fluoro-1H-indol-3-yl)acetate
CAS No.:319-69-7
Molecular Formula:C12H12FNO2
Molecular Weight:221.231
Hs Code.:2933990090
DSSTox Substance ID:DTXSID30582743
Wikidata:Q82474238
Mol file:319-69-7.mol

Synonyms:319-69-7;Ethyl 5-Fluoroindole-3-acetate;ethyl (5-fluoro-1H-indol-3-yl)acetate;ETHYL 2-(5-FLUORO-1H-INDOL-3-YL)ACETATE;(5-fluoro-1H-indol-3-yl)acetic acid ethyl ester;1h-indole-3-acetic acid,5-fluoro-,ethyl ester;SCHEMBL5189543;DTXSID30582743;FYNLEVUFIFSEEW-UHFFFAOYSA-N;AC5884;MFCD12912001;AKOS024171598;SY058579;A914024

Suppliers and Price of ethyl (5-fluoro-1H-indol-3-yl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
Ethyl(5-fluoro-1H-indol-3-yl)acetate
1g
$ 1275.00

AccelPharmtech
ethyl2-(5-fluoro-1H-indol-3-yl)acetate 97.00%
25G
$ 5120.00

AccelPharmtech
ethyl2-(5-fluoro-1H-indol-3-yl)acetate 97.00%
5G
$ 2750.00

AccelPharmtech
ethyl2-(5-fluoro-1H-indol-3-yl)acetate 97.00%
1G
$ 2370.00

Total 8 raw suppliers

Chemical Property of ethyl (5-fluoro-1H-indol-3-yl)acetate

Chemical Property:

PSA：42.09000
LogP:2.41260
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:221.08520679
Heavy Atom Count:16
Complexity:259

Purity/Quality:

97% ^*data from raw suppliers

Ethyl(5-fluoro-1H-indol-3-yl)acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)CC1=CNC2=C1C=C(C=C2)F

Technology Process of ethyl (5-fluoro-1H-indol-3-yl)acetate

There total 9 articles about ethyl (5-fluoro-1H-indol-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: C₁₂H₁₀FNO₂^(2-)

: 319-69-7
(5-fluoro-1H-indol-3-yl)acetic acid ethyl ester

Guidance literature:: With iron(III) tris(2,2,6,6-tetramethyl-3,5-heptanedionate); phenylsilane; In 1,2-dichloro-ethane; isopropyl alcohol; at 35 ℃; for 2h;
DOI:10.1039/d1sc03058b

Reference yield: 51.0%

: (2E,4E)-4-[2-(4-fluorophenyl)hydrazono]-2-butenoic acid ethyl ester

: 319-69-7
(5-fluoro-1H-indol-3-yl)acetic acid ethyl ester

Guidance literature:: With tert-Butyl iodide; In acetonitrile; for 0.5h; Reflux;
DOI:10.1002/chem.201504010

Reference yield: 44.0%

: 399-52-0
5-fluoro-1H-indole

: 105-36-2
ethyl bromoacetate

: 319-69-7
(5-fluoro-1H-indol-3-yl)acetic acid ethyl ester

Guidance literature:: 5-fluoro-1H-indole; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.25h;

With zinc(II) chloride; In tetrahydrofuran; diethyl ether; hexane; for 24h;

ethyl bromoacetate; In toluene; for 24h;
DOI:10.1021/jm060910c