2-HEXYLSUCCINIC ACID

Base Information

• Chemical Name: 2-HEXYLSUCCINIC ACID
• CAS No.: 5702-91-0
• Molecular Formula: C10H18O4
• Molecular Weight: 202.25
• Mol file: 5702-91-0.mol

Synonyms:1,2-Octanedicarboxylic acid;n-Hexyl-bernsteinsaeure;2-n-Hexyl-succinsaeure;n-hexyl succinic acid;Butanedioic acid,hexyl;2-hexylsuccinic acid;

Chemical Property of 2-HEXYLSUCCINIC ACID

Chemical Property:

• PSA: 74.60000
• LogP: 2.13230

Purity/Quality:

97% ^*data from raw suppliers

2-HEXYLSUCCINIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HEXYLSUCCINIC ACID

There total 20 articles about 2-HEXYLSUCCINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl-2-bromooctanoate (138286-76-7,5445-29-4) → 2-hexylsuccinic acid (5702-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaOEt, (ii) aq. NaOH

2: 140 °C

Reference yield:

n-octyne (629-05-0) + carbon dioxide (124-38-9,18923-20-1) → 2-hexylsuccinic acid (5702-91-0)

Guidance literature:

With dibromobis(triphenylphosphine)nickel(II); tetrabutylammonium tetrafluoroborate; triphenylphosphine; In N,N-dimethyl-formamide; at 70 ℃; for 15h; magnesium anode, carbon fibre cathode, 50 mA;

DOI:10.1016/0022-328X(88)80330-9

Reference yield:

methyl 2-nonenoate (111-79-5) → 2-hexylsuccinic acid (5702-91-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Ph₂CO / 2-methyl-propan-2-ol / Irradiation

2: (alkaline hydrolysis)

With benzophenone; In tert-butyl alcohol;

DOI:10.1021/jo01350a078

upstream raw materials:

hexylsuccinic acid anhydride

hex-2-enyl-succinic acid

2,3-dicyano-nonanoic acid ethyl ester

octane-1,1,2-tricarboxylic acid

Downstream raw materials:

(2R)-2-cyclohexylsuccinic acid

(-)-(S)-2-Hexylsuccinic acid

D(+)-n-Hexylbernsteinsaeure

Refernces

• 1、 Chadha, Vijay K.,Leidal, Kevin G.,Plapp, Bryce V.. "Inhibition of Liver Alcohol Dehydrogenase and Ethanol Metabolism by 3-Substituted Thiolane 1-Oxides". . p. 36 - 40. Retrieved 2007/10/02.