(2R)-2-cyclohexylsuccinic acid

Base Information

• Chemical Name: (2R)-2-cyclohexylsuccinic acid
• CAS No.: 136570-32-6
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 200.235

Synonyms:(2R)-2-cyclohexylsuccinic acid

Chemical Property of (2R)-2-cyclohexylsuccinic acid

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Technology Process of (2R)-2-cyclohexylsuccinic acid

There total 8 articles about (2R)-2-cyclohexylsuccinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N,N'-<(2R)-2-cyclohexylsuccinyl>bis(1,3:4,6-di-O-benzylidene-2,5-dideoxy-2,5-imino-L-iditol) → (2R)-2-cyclohexylsuccinic acid (136570-32-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 24h; Heating;

DOI:10.1002/hlca.19930760128

Reference yield: 77.0%

R-(+)-phenylsuccinic acid (46292-93-7) → (2R)-2-cyclohexylsuccinic acid (136570-32-6)

Guidance literature:

With hydrogen; Rh/Al₂O₃; In methanol; for 16h; Ambient temperature;

DOI:10.1002/hlca.19930760128

Reference yield:

2-[(S)-2-((S)-4-tert-Butyl-2,2-dimethyl-oxazolidin-3-yl)-1-cyclohexyl-2-oxo-ethyl]-malonic acid dimethyl ester (136570-30-4) → (2R)-2-cyclohexylsuccinic acid (136570-32-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1021/ja00020a066

upstream raw materials:

2-cyclohexylsuccinic acid

R-(+)-phenylsuccinic acid

2-[(S)-2-((S)-4-tert-Butyl-2,2-dimethyl-oxazolidin-3-yl)-1-cyclohexyl-2-oxo-ethyl]-malonic acid dimethyl ester

2-hexylsuccinic acid

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