1-(Tosyloxy)-2,3-diphenylindolizine-7-carbonitrile

Base Information

Chemical Name:1-(Tosyloxy)-2,3-diphenylindolizine-7-carbonitrile
CAS No.:321909-82-4
Molecular Formula:C28H20N2O3S
Molecular Weight:464.544
Hs Code.:
DSSTox Substance ID:DTXSID701152584
Nikkaji Number:J1.434.108K
ChEMBL ID:CHEMBL1916429
Mol file:321909-82-4.mol

Synonyms:CHEMBL1916429;DTXSID701152584;BDBM50357002;1-(Tosyloxy)-2,3-diphenylindolizine-7-carbonitrile;1-[[(4-Methylphenyl)sulfonyl]oxy]-2,3-diphenyl-7-indolizinecarbonitrile;321909-82-4

Suppliers and Price of 1-(Tosyloxy)-2,3-diphenylindolizine-7-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(Tosyloxy)-2,3-diphenylindolizine-7-carbonitrile

Chemical Property:

XLogP3:7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:464.11946368
Heavy Atom Count:34
Complexity:825

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)OC2=C3C=C(C=CN3C(=C2C4=CC=CC=C4)C5=CC=CC=C5)C#N

Technology Process of 1-(Tosyloxy)-2,3-diphenylindolizine-7-carbonitrile

There total 3 articles about 1-(Tosyloxy)-2,3-diphenylindolizine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 86203-32-9
7-cyano-2,3-diphenyl-1-indolizinol

: 98-59-9
p-toluenesulfonyl chloride

: 321909-82-4
7-cyano-2,3-diphenylindolizin-1-yl tosylate

Guidance literature:: With dmap; In 1,2-dichloro-ethane; at 0 - 20 ℃; for 24h;
DOI:10.1002/1099-0690(200011)2000:22<3763::AID-EJOC3763>3.0.CO;2-S

Reference yield:

: 100-48-1
pyridine-4-carbonitrile

: 321909-82-4
7-cyano-2,3-diphenylindolizin-1-yl tosylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 16 h / Heating

2: 73 percent / DMAP / 1,2-dichloro-ethane / 24 h / 0 - 20 °C

With dmap; In 1,2-dichloro-ethane; 1: Cyclization / 2: Tosylation;
DOI:10.1002/1099-0690(200011)2000:22<3763::AID-EJOC3763>3.0.CO;2-S

Reference yield:

: 886-38-4
diphenylcyclopropenone

: 321909-82-4
7-cyano-2,3-diphenylindolizin-1-yl tosylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,2-dichloro-ethane / 16 h / Heating

2: 73 percent / DMAP / 1,2-dichloro-ethane / 24 h / 0 - 20 °C

With dmap; In 1,2-dichloro-ethane; 1: Cyclization / 2: Tosylation;
DOI:10.1002/1099-0690(200011)2000:22<3763::AID-EJOC3763>3.0.CO;2-S