86203-32-9

Upstream product

• 100-48-1 pyridine-4-carbonitrile 
• 886-38-4 diphenylcyclopropenone 
• 121572-71-2 C₂₁H₁₃N₂O 

Downstream Products

• 121572-71-2 C₂₁H₁₃N₂O 
• 121572-89-2 7-Cyano-1-oxo-2,3-diphenyl-1H-indolizinylium; bromide 
• 121573-09-9 C₂₁H₁₃N₂O⁽¹⁺⁾*I₃^(1-) 
• 180601-77-8 1-methoxy-2,3-diphenylindolizine-7-carbonitrile 
• 660414-49-3 3-methoxy-benzoic acid 7-cyano-2,3-diphenyl-indolizin-1-yl ester 
• 660414-44-8 1-(3-chloro-benzyloxy)-2,3-diphenyl-indolizine-7-carbonitrile 
• 660414-40-4 1-(4-chloro-benzyloxy)-2,3-diphenyl-indolizine-7-carbonitrile 
• 660414-48-2 4-methoxy-benzoic acid 7-cyano-2,3-diphenyl-indolizin-1-yl ester 
• 660414-45-9 1-(2-methoxy-benzyloxy)-2,3-diphenyl-indolizine-7-carbonitrile 
• 660414-43-7 1-(4-methoxy-benzyloxy)-2,3-diphenyl-indolizine-7-carbonitrile 
• 660414-42-6 1-(4-methyl-benzyloxy)-2,3-diphenyl-indolizine-7-carbonitrile 
• 660414-50-6 2-methoxy-benzoic acid 7-cyano-2,3-diphenyl-indolizin-1-yl ester 
• 660414-46-0 1-benzyloxymethoxy-2,3-diphenyl-indolizine-7-carbonitrile 
• 852063-84-4 2,4,6-trimethyl-benzenesulfonic acid 7-cyano-2,3-diphenyl-indolizin-1-yl ester 

Relevant academic research and scientific papers

Indolizine 1-sulfonates as potent inhibitors of 15-lipoxygenase from soybeans

A number of indolizine 1-sulfonates have been prepared by cyclization of cyclopropenones with pyridines followed by trapping of the intermediate 1-indolizinol with a sulfonyl halide, and examined as inhibitors of 15-lipoxygenase (15-LO). The compounds dis

Indolizines as novel potent inhibitors of 15-Lipoxygenase

15-Lipoxygenase (15-LO) has been implicated in oxidation of low-density lipoproteins (LDL) and this enzyme may be involved in the development of atherosclerosis. We have examined 1-substituted indolizines as possible inhibitors of 15-LO from soy beans and from rabbit reticulocytes. Most compounds studied were significantly more active as inhibitors of 15-LO from soy beans than quercetin. The indolizines were slightly less potent inhibitors of the mammalian enzyme, but we found good correlation between inhibitory activity against both 15-LO enzymes studied. Several of the compounds were only weak DPPH scavengers and they may therefore be regarded as so-called non antioxidant inhibitors of 15-LO.

Synthesis of 1-substituted 7-cyano-2,3-diphenylindolizines and evaluation of antioxidant properties

Protocols for the synthesis of novel 1-substituted 7-cyano-2,3-diphenylindolizines from the corresponding indolizinol have been developed, and the compounds' abilities to act as antioxidants, i.e. to inhibit lipid peroxidation in vitro, have been examined

Use of persistent heterocyclic free-radicals in magnetic resonance imaging

The present invention provides the use of a persistent ?-system free radical for the manufacture of a contrast medium for use in magnetic resonance imaging, wherein the electron delocalising ?-system of said radical comprises at least one homo or heterocy

Indolizines. 3. Oxidation Products of Indolizinols: Radicals, Ions, and Oxidized Dimers

The oxidation products of 1- and 3-indolizinols have been investigated and characterized.A variety of stabilized indolizinols form stable, crystalline free radicals by one-electron oxidations.Both 7-H and 7-CH3 substituted indolizinols, when subjected to the exhaustive aerial or benzoquinone oxidation, from the oxidatively coupled 1,1'- or 3,3'-dioxo-7,7'-bisindolizines.Two-electron oxidation of indolizinols formed oxoindolizinium ions.

Indolizines. 2. Preparation of 1- and 3-Indolizinols and Their Esters

2,3-Diarylcyclopropenones react smoothly with pyridine and substituted pyridines in a variety of solvents to produce 1- and/or 3-indolizinols.The regioisomeric indolizines were characterized by X-ray crystallography of their acetate derivatives.The synthesis and spectroscopic properties of a number of indolizinols and their ester derivatives are described.