3,5-BIS(TRIFLUOROMETHYL)-N-(BROMOACETYL)ANILINE

Base Information

• Chemical Name: 3,5-BIS(TRIFLUOROMETHYL)-N-(BROMOACETYL)ANILINE
• CAS No.: 99468-72-1
• Molecular Formula: C10H6BrF6NO
• Molecular Weight: 350.058
• Hs Code.: 2924299090
• Mol file: 99468-72-1.mol

Synonyms:

Chemical Property of 3,5-BIS(TRIFLUOROMETHYL)-N-(BROMOACETYL)ANILINE

Chemical Property:

• Vapor Pressure: 0.00066mmHg at 25°C
• Melting Point: 100-101
• Boiling Point: 308.9°Cat760mmHg
• Flash Point: 140.6°C
• PSA: 29.10000
• Density: 1.726g/cm³
• LogP: 4.13060

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Bis(trifluoromethyl)-N-(bromoacetyl)aniline 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,5-Bis(trifluoromethyl)-N-(bromoacetyl)aniline (CAS# 99468-72-1) can be used to prepare medical plastic pipes. It can also be used as pesticides and herbicides.

Technology Process of 3,5-BIS(TRIFLUOROMETHYL)-N-(BROMOACETYL)ANILINE

There total 2 articles about 3,5-BIS(TRIFLUOROMETHYL)-N-(BROMOACETYL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Bromoacetyl bromide (598-21-0) + 3,5-Bis-(trifluoromethyl)aniline (328-74-5) → N-[3,5-bis(trifluoromethyl)phenyl]-2-bromoacetamide (99468-72-1)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 0 ℃; for 1h;

DOI:10.1021/acs.orglett.9b03065

Reference yield:

2-bromoacetyl chloride (22118-09-8) + 3,5-Bis-(trifluoromethyl)aniline (328-74-5) → N-[3,5-bis(trifluoromethyl)phenyl]-2-bromoacetamide (99468-72-1)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Cooling; Inert atmosphere;

DOI:10.1021/ja9004859

Reference yield:

N-[3,5-bis(trifluoromethyl)phenyl]-2-bromoacetamide (99468-72-1) + (+)-aloperine (56293-29-9) → 12N-(N'-(3,5-ditrifluoromethylphenyl)carbamoylmethyl)aloperine

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bioorg.2021.105196

upstream raw materials:

2-bromoacetyl chloride

3,5-Bis-(trifluoromethyl)aniline

2-Bromoacetyl bromide

Downstream raw materials:

C₁₆H₁₈F₆N₂O

C₂₂H₂₃F₆N₃O

N-(3,5-bis(trifluoromethyl)phenyl)-2-(piperazin-1-yl)acetamide hydrochloride

C₂₁H₂₁F₆N₃O